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Dovile Sinkeviciute

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Articles 12
Citations 193
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Recent Articles
1.
Madsen S, Sinkeviciute D, Thudium C, Karsdal M, Bay-Jensen A
Sci Rep . 2024 May; 14(1):10751. PMID: 38730088
Type III collagen gene expression is upregulated in the synovium of patients with rheumatoid arthritis (RA) presenting the fibroid phenotype. The soluble type III collagen formation biomarker, PRO-C3, is known...
2.
Port H, Hausgaard C, He Y, Maksymowych W, Wichuk S, Sinkeviciute D, et al.
Sci Rep . 2023 Dec; 13(1):21717. PMID: 38066013
Rheumatic joints have an altered cartilage turnover. Cartilage intermediate layer protein 1 (CILP-1) is secreted from articular chondrocytes and deposited into the cartilage extracellular matrix. We developed an immunoassay targeting...
3.
Ghiboub M, Bell M, Sinkeviciute D, Prinjha R, de Winther M, Harker N, et al.
Curr Issues Mol Biol . 2023 May; 45(5):4228-4245. PMID: 37232738
SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between single nucleotide polymorphisms (SNPs) and diverse autoimmune and inflammatory diseases, suggesting a...
4.
Drobinski P, Nissen N, Sinkeviciute D, Willumsen N, Karsdal M, Bay-Jensen A
Int J Mol Sci . 2023 Jan; 24(1). PMID: 36613765
Protein citrullination and degradation by matrix metalloproteinases (MMP) plays a central role in the pathology of rheumatoid arthritis (RA). Autoantibodies are known to target citrullinated vimentin. The aim of this...
5.
Groen S, Sinkeviciute D, Bay-Jensen A, Thudium C, Karsdal M, Thomsen S, et al.
Osteoarthr Cartil Open . 2022 Dec; 3(4):100207. PMID: 36474766
Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and...
6.
Holm Nielsen S, Magee C, Groen S, Sinkeviciute D, Bay-Jensen A, Karsdal M, et al.
Clin Exp Rheumatol . 2022 Aug; 41(3):574-580. PMID: 35916294
Objectives: Around 30% of patients diagnosed with cutaneous psoriasis (PsC) will go on to develop psoriatic arthritis (PsA) which includes inflammation of the joints. Collagens are core proteins in all...
7.
Mortensen J, Sinkeviciute D, Manon-Jensen T, Domislovic V, McCall K, Thudium C, et al.
J Crohns Colitis . 2022 Mar; 16(9):1447-1460. PMID: 35304895
Background And Aims: Endoscopy and the use of faecal calprotectin [faecal CP] are among the least-favoured methods for assessing disease activity by inflammatory bowel disease [IBD] patients; the handling/processing of...
8.
Groen S, Sinkeviciute D, Bay-Jensen A, Thudium C, Karsdal M, Thomsen S, et al.
Autoimmun Rev . 2021 Jan; 20(3):102760. PMID: 33485992
Spondyloarthritis (SpA) is an umbrella term describing a family of chronic inflammatory rheumatic diseases. These diseases are characterised by inflammation of the axial skeleton, peripheral joints, and entheseal insertion sites...
9.
Jensen C, Sinkeviciute D, Madsen D, Onnerfjord P, Hansen M, Schmidt H, et al.
Cancers (Basel) . 2020 Oct; 12(10). PMID: 32998446
A T-cell permissive tumor microenvironment, characterized by the presence of activated T cells and low fibrotic activity is crucial for response to immune checkpoint inhibitors (ICIs). Granzyme B has been...
10.
Sinkeviciute D, Groen S, Sun S, Manon-Jensen T, Aspberg A, Onnerfjord P, et al.
Sci Rep . 2020 Aug; 10(1):13541. PMID: 32782251
Psoriatic arthritis (PsA) is a chronic musculoskeletal inflammatory disease found in up to 30% of psoriasis patients. Prolargin-an extracellular matrix (ECM) protein present in cartilage and tendon-has been previously shown...