Douglas M Heithoff
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Explore the profile of Douglas M Heithoff including associated specialties, affiliations and a list of published articles.
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31
Citations
557
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Recent Articles
1.
Yang W, Aziz P, Heithoff D, Kim Y, Ko J, Cho J, et al.
iScience
. 2023 Sep;
26(10):107883.
PMID: 37752945
The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms...
2.
Barnes V L, Heithoff D, Mahan S, House J, Mahan M
STAR Protoc
. 2023 Aug;
4(3):102512.
PMID: 37566547
Antimicrobial susceptibility testing is used to determine the minimum inhibitory concentration (MIC), the standard measurement of antibiotic activity. Here, we present a protocol for evaluating MIC values of clinically relevant...
3.
Heithoff D, Barnes V L, Mahan S, Fried J, Fitzgibbons L, House J, et al.
Cell Rep Med
. 2023 Apr;
4(5):101023.
PMID: 37116500
Accurate assessment of antibiotic susceptibility is critical for treatment of antimicrobial resistant (AMR) infections. Here, we examine whether antimicrobial susceptibility testing in media more physiologically representative of in vivo conditions...
4.
Heithoff D, Mahan S, Barnes V L, Leyn S, George C, Zlamal J, et al.
EBioMedicine
. 2023 Feb;
89:104461.
PMID: 36801104
Background: Antimicrobial resistance (AMR) poses a critical threat to public health and disproportionately affects the health and well-being of persons in low-income and middle-income countries. Our aim was to identify...
5.
Haslund-Gourley B, Aziz P, Heithoff D, Restagno D, Fried J, Ilse M, et al.
PNAS Nexus
. 2022 Aug;
1(3):pgac113.
PMID: 35967980
Glycosidases are hydrolytic enzymes studied principally in the context of intracellular catabolism within the lysosome. Therefore, glycosidase activities are classically measured in experimentally acidified assay conditions reflecting their low pH...
6.
Heithoff D, Pimienta G, Mahan S, Yang W, Le D, House J, et al.
EBioMedicine
. 2022 Mar;
78:103965.
PMID: 35349828
Background: Although sepsis accounts for 1 in 5 deaths globally, few molecular therapies exist for this condition. The development of effective biomarkers and treatments for sepsis requires a more complete...
7.
Heithoff D, Barnes 5th L, Mahan S, Fox G, Arn K, Ettinger S, et al.
JAMA Netw Open
. 2022 Jan;
5(1):e2145669.
PMID: 35089353
Importance: A critical need exists in low-income and middle-income countries for low-cost, low-tech, yet highly reliable and scalable testing for SARS-CoV-2 virus that is robust against circulating variants. Objective: To...
8.
Yang W, Westman J, Heithoff D, Sperandio M, Cho J, Mahan M, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(29).
PMID: 34266954
Intestinal inflammation is the underlying basis of colitis and the inflammatory bowel diseases. These syndromes originate from genetic and environmental factors that remain to be fully identified. Infections are possible...
9.
Pimienta G, Heithoff D, Rosa-Campos A, Tran M, Esko J, Mahan M, et al.
Proteomics
. 2019 Feb;
19(5):e1800389.
PMID: 30706660
Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise. Despite more than three decades...
10.
Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis
Yang W, Heithoff D, Aziz P, Haslund-Gourley B, Westman J, Narisawa S, et al.
Cell Host Microbe
. 2018 Oct;
24(4):500-513.e5.
PMID: 30308156
Sepsis is a life-threatening inflammatory syndrome accompanying a bloodstream infection. Frequently secondary to pathogenic bacterial infections, sepsis remains difficult to treat as a singular disease mechanism. We compared the pathogenesis...