Douglas M Bennion
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Explore the profile of Douglas M Bennion including associated specialties, affiliations and a list of published articles.
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17
Citations
268
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Recent Articles
11.
Bennion D, Isenberg J, Harmel A, DeMars K, Dang A, Jones C, et al.
PLoS One
. 2017 Jul;
12(7):e0180738.
PMID: 28671997
Activation of the angiotensin II type 2 receptor (AT2R) by administration of Compound 21 (C21), a selective AT2R agonist, induces neuroprotection in models of ischemic stroke in young adult animals....
12.
Bennion D, Rosado C, Haltigan E, Regenhardt R, Sumners C, Waters M
J Renin Angiotensin Aldosterone Syst
. 2016 Aug;
17(3).
PMID: 27488276
Levels of angiotensin converting enzyme 2 (ACE2), a cardio and neuro-protective carboxypeptidase, are dynamically altered after stroke in preclinical models. We sought to characterize the previously unexplored changes in serum...
13.
Bennion D, Haltigan E, Irwin A, Donnangelo L, Regenhardt R, Pioquinto D, et al.
Hypertension
. 2015 May;
66(1):141-8.
PMID: 25941346
The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis represents a promising target for inducing stroke neuroprotection. Here, we explored stroke-induced changes in expression and activity of endogenous angiotensin-converting enzyme 2 and other system...
14.
Bennion D, Haltigan E, Regenhardt R, Steckelings U, Sumners C
Curr Hypertens Rep
. 2015 Jan;
17(2):3.
PMID: 25620630
The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms...
15.
Wegman M, Guo M, Bennion D, Shankar M, Chrzanowski S, Goldberg L, et al.
Rejuvenation Res
. 2014 Dec;
18(2):162-72.
PMID: 25546413
Caloric restriction has consistently been shown to extend life span and ameliorate aging-related diseases. These effects may be due to diet-induced reactive oxygen species acting to up-regulate sirtuins and related...
16.
Joseph J, Mecca A, Regenhardt R, Bennion D, Rodriguez V, Desland F, et al.
Neuropharmacology
. 2014 Feb;
81:134-41.
PMID: 24508710
Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exert beneficial effects in...
17.
Regenhardt R, Bennion D, Sumners C
Clin Sci (Lond)
. 2013 Oct;
126(3):195-205.
PMID: 24102099
The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin-angiotensin system) in stroke, with particular focus on Ang-(1-7) [angiotensin-(1-7)] and...