Douglas H Pike
Overview
Explore the profile of Douglas H Pike including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
340
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Recent Articles
1.
Timm J, Pike D, Mancini J, Tyryshkin A, Poudel S, Siess J, et al.
Sci Adv
. 2023 Mar;
9(10):eabq1990.
PMID: 36897954
Ancestral metabolic processes involve the reversible oxidation of molecular hydrogen by hydrogenase. Extant hydrogenase enzymes are complex, comprising hundreds of amino acids and multiple cofactors. We designed a 13-amino acid...
2.
Reed B, Meyer M, Abramzon V, Ad O, Adcock P, Ahmad F, et al.
Science
. 2022 Oct;
378(6616):186-192.
PMID: 36227977
Studies of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect posttranslational modifications with single-molecule sensitivity. Here, we demonstrate single-molecule protein sequencing using...
3.
McCann J, Pike D, Brown M, Crouse D, Nanda V, Koder R
Sci Adv
. 2022 Jul;
8(27):eabh3421.
PMID: 35857443
The VX nerve agent is one of the deadliest chemical warfare agents. Specific, sensitive, real-time detection methods for this neurotoxin have not been reported. The creation of proteins that use...
4.
Poudel S, Pike D, Raanan H, Mancini J, Nanda V, Rickaby R, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(48):30451-30457.
PMID: 33199597
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the most abundant enzyme on Earth. However, its catalytic rate per molecule of protein is extremely slow and the binding of the primary substrate, CO,...
5.
Jagilinki B, Ilic S, Trncik C, Tyryshkin A, Pike D, Lubitz W, et al.
ACS Synth Biol
. 2020 Nov;
9(12):3400-3407.
PMID: 33186033
expression of metalloproteins requires specific metal trafficking and incorporation machinery inside the cell. Synthetic designed metalloproteins are typically purified without the target metal, which is subsequently introduced through reconstitution. The...
6.
Mancini J, Pike D, Tyryshkin A, Haramaty L, Wang M, Poudel S, et al.
Biotechnol Appl Biochem
. 2020 Aug;
67(4):574-585.
PMID: 32770861
We explore the capacity of the de novo protein, S824, to incorporate a multinuclear iron-sulfur cluster within the core of a single-chain four-helix bundle. This topology has a high intrinsic...
7.
Raanan H, Poudel S, Pike D, Nanda V, Falkowski P
Proc Natl Acad Sci U S A
. 2020 Mar;
117(13):7193-7199.
PMID: 32188785
Life on Earth is driven by electron transfer reactions catalyzed by a suite of enzymes that comprise the superfamily of oxidoreductases (Enzyme Classification EC1). Most modern oxidoreductases are complex in...
8.
Kim J, Pike D, Tyryshkin A, Swapna G, Raanan H, Montelione G, et al.
J Am Chem Soc
. 2018 Aug;
140(36):11210-11213.
PMID: 30141918
Ambidoxin is a designed, minimal dodecapeptide consisting of alternating L and D amino acids that binds a 4Fe-4S cluster through ligand-metal interactions and an extensive network of second-shell hydrogen bonds....
9.
James J, Pike D, Khan I, Nanda V
Structure
. 2018 Jun;
26(7):997-1006.e5.
PMID: 29887498
To what extent do structural and biophysical features of food allergen proteins distinguish them from other proteins in our diet? Invertebrate tropomyosins (Tpms) as a class are considered "pan-allergens," inducing...
10.
Raanan H, Pike D, Moore E, Falkowski P, Nanda V
Proc Natl Acad Sci U S A
. 2018 Jan;
115(6):1280-1285.
PMID: 29358375
Oxidoreductases catalyze electron transfer reactions that ultimately provide the energy for life. A limited set of ancestral protein-metal modules are presumably the building blocks that evolved into this diverse protein...