Douglas D Lemon
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Explore the profile of Douglas D Lemon including associated specialties, affiliations and a list of published articles.
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11
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551
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Recent Articles
1.
Blakeslee W, Demos-Davies K, Lemon D, Lutter K, Cavasin M, Payne S, et al.
Pediatr Res
. 2017 May;
82(4):642-649.
PMID: 28549058
BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with...
2.
Lemon D, Harrison B, Horn T, Stratton M, Ferguson B, Wempe M, et al.
FEBS Lett
. 2015 Mar;
589(10):1080-8.
PMID: 25816750
PKD-mediated phosphorylation of class IIa HDACs frees the MEF2 transcription factor to activate genes that govern muscle differentiation and growth. Studies of the regulation and function of this signaling axis...
3.
Marquardt D, Doyle M, Davidson J, Epp J, Aitken J, Lemon D, et al.
J Funct Biomater
. 2014 Jun;
3(1):61-78.
PMID: 24956516
A recombinant 130 kDa dihemoglobin which is made up of a single-chain tetra-α globin and four β globins has been expressed as a soluble protein in E. coli. The sequence...
4.
Cavasin M, Demos-Davies K, Horn T, Walker L, Lemon D, Birdsey N, et al.
Circ Res
. 2012 Jan;
110(5):739-48.
PMID: 22282194
Rationale: Histone deacetylase (HDAC) inhibitors are efficacious in models of hypertension-induced left ventricular heart failure. The consequences of HDAC inhibition in the context of pulmonary hypertension with associated right ventricular...
5.
Li M, Riddle S, Frid M, El Kasmi K, McKinsey T, Sokol R, et al.
J Immunol
. 2011 Aug;
187(5):2711-22.
PMID: 21813768
Persistent accumulation of monocytes/macrophages in the pulmonary artery adventitial/perivascular areas of animals and humans with pulmonary hypertension has been documented. The cellular mechanisms contributing to chronic inflammatory responses remain unclear....
6.
Lemon D, Horn T, Cavasin M, Jeong M, Haubold K, Long C, et al.
J Mol Cell Cardiol
. 2011 May;
51(1):41-50.
PMID: 21539845
Small molecule histone deacetylase (HDAC) inhibitors block adverse cardiac remodeling in animal models of heart failure. The efficacious compounds target class I, class IIb and, to a lesser extent, class...
7.
Lemon D, Papst P, Joly K, Plato C, McKinsey T
Anal Biochem
. 2010 Sep;
408(1):132-5.
PMID: 20816744
Stress signaling in the myocardium results in enhanced expression of fetal β-myosin heavy chain (β-MyHC) and reduced expression of adult α-myosin heavy chain (α-MyHC), with the net outcome of diminished...
8.
Meredith E, Beattie K, Burgis R, Capparelli M, Chapo J, DiPietro L, et al.
J Med Chem
. 2010 Aug;
53(15):5422-38.
PMID: 20684592
The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The...
9.
Monovich L, Vega R, Meredith E, Miranda K, Rao C, Capparelli M, et al.
FEBS Lett
. 2009 Dec;
584(3):631-7.
PMID: 20018189
Class IIa histone deacetylases (HDACs) repress genes involved in pathological cardiac hypertrophy. The anti-hypertrophic action of class IIa HDACs is overcome by signals that promote their phosphorylation-dependent nuclear export. Several...
10.
Kim M, Fielitz J, McAnally J, Shelton J, Lemon D, McKinsey T, et al.
Mol Cell Biol
. 2008 Apr;
28(11):3600-9.
PMID: 18378694
Skeletal muscle consists of type I and type II myofibers, which exhibit different metabolic and contractile properties. Type I fibers display an oxidative metabolism and are resistant to fatigue, whereas...