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Douglas Brubaker

Explore the profile of Douglas Brubaker including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 41
Followers 0
Related Specialties
Biology
Molecular Biology
Genetics
Top 10 Co-Authors
Sam Mesiano
Mark R Chance
Gurkan Bebek
Ge Zhang
Alina Starchenko
Bo Jacobsson
Jill Barnholtz-Sloan
Yu Liu
Mark Chance
Irina A Buhimschi
Published In
Pac Symp Biocomput
Biol Reprod
BMC Syst Biol
Integr Biol (Camb)
Hum Mol Genet
Affiliations
Soon will be listed here.
Recent Articles
1.
Cell surface integrin α5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3
Starchenko A, Graves-Deal R, Brubaker D, Li C, Yang Y, Singh B, et al.
Integr Biol (Camb) . 2021 May; 13(6):153-166. PMID: 34037774
As a key process within the tissue microenvironment, integrin signaling can influence cell functional responses to growth factor stimuli. We show here that clustering of integrin α5ß1 at the plasma...
2.
Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor
Ackerman 4th W, Buhimschi I, Brubaker D, Maxwell S, Rood K, Chance M, et al.
Biol Reprod . 2018 Feb; 98(6):834-845. PMID: 29447339
We conducted integrated transcriptomics network analyses of miRNA and mRNA interactions in human myometrium to identify novel molecular candidates potentially involved in human parturition. Myometrial biopsies were collected from women...
3.
FREQUENT SUBGRAPH MINING OF PERSONALIZED SIGNALING PATHWAY NETWORKS GROUPS PATIENTS WITH FREQUENTLY DYSREGULATED DISEASE PATHWAYS AND PREDICTS PROGNOSIS
Durmaz A, Henderson T, Brubaker D, Bebek G
Pac Symp Biocomput . 2016 Nov; 22:402-413. PMID: 27896993
Motivation: Large scale genomics studies have generated comprehensive molecular characterization of numerous cancer types. Subtypes for many tumor types have been established; however, these classifications are based on molecular characteristics...
4.
Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth
Brubaker D, Liu Y, Wang J, Tan H, Zhang G, Jacobsson B, et al.
Hum Mol Genet . 2016 Sep; 25(23):5254-5264. PMID: 27664809
Maternal genome influences associate with up to 40% of spontaneous preterm births (PTB). Multiple genome wide association studies (GWAS) have been completed to identify genetic variants associated with PTB. Disappointingly,...
5.
A dynamical systems model of progesterone receptor interactions with inflammation in human parturition
Brubaker D, Barbaro A, Chance M, Mesiano S
BMC Syst Biol . 2016 Aug; 10(1):79. PMID: 27543267
Background: Progesterone promotes uterine relaxation and is essential for the maintenance of pregnancy. Withdrawal of progesterone activity and increased inflammation within the uterine tissues are key triggers for parturition. Progesterone...
6.
Drug Intervention Response Predictions with PARADIGM (DIRPP) identifies drug resistant cancer cell lines and pathway mechanisms of resistance
Brubaker D, DiFeo A, Chen Y, Pearl T, Zhai K, Bebek G, et al.
Pac Symp Biocomput . 2013 Dec; :125-35. PMID: 24297540
The revolution in sequencing techniques in the past decade has provided an extensive picture of the molecular mechanisms behind complex diseases such as cancer. The Cancer Cell Line Encyclopedia (CCLE)...