Dorothee Caille
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Explore the profile of Dorothee Caille including associated specialties, affiliations and a list of published articles.
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31
Citations
1615
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Recent Articles
1.
Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice
Motterle A, Gattesco S, Caille D, Meda P, Regazzi R
Diabetologia
. 2015 Jun;
58(8):1827-35.
PMID: 26037202
Aims/hypothesis: Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immune cells induces alterations in gene expression, leading to impaired insulin secretion and apoptosis in the initial phases of...
2.
Haefliger J, Rohner-Jeanrenaud F, Caille D, Charollais A, Meda P, Allagnat F
J Mol Endocrinol
. 2013 Apr;
51(1):49-58.
PMID: 23613279
Channels formed by the gap junction protein Connexin36 (CX36) contribute to the proper control of insulin secretion. We previously demonstrated that chronic exposure to glucose decreases Cx36 levels in insulin-secreting...
3.
Martin D, Allagnat F, Gesina E, Caille D, Gjinovci A, Waeber G, et al.
PLoS One
. 2012 Oct;
7(9):e45844.
PMID: 23029270
The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These...
4.
Roggli E, Gattesco S, Caille D, Briet C, Boitard C, Meda P, et al.
Diabetes
. 2012 Apr;
61(7):1742-51.
PMID: 22537941
During the initial phases of type 1 diabetes, pancreatic islets are invaded by immune cells, exposing β-cells to proinflammatory cytokines. This unfavorable environment results in gene expression modifications leading to...
5.
Klee P, Allagnat F, Pontes H, Cederroth M, Charollais A, Caille D, et al.
J Clin Invest
. 2011 Nov;
121(12):4870-9.
PMID: 22056383
Type 1 diabetes develops when most insulin-producing β cells of the pancreas are killed by an autoimmune attack. The in vivo conditions modulating the sensitivity and resistance of β cells...
6.
Santiago M, Veliskova J, Patel N, Lutz S, Caille D, Charollais A, et al.
PLoS One
. 2011 Sep;
6(9):e25178.
PMID: 21949881
Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been implicated in epilepsy. However, little is known...
7.
Woodfin A, Voisin M, Beyrau M, Colom B, Caille D, Diapouli F, et al.
Nat Immunol
. 2011 Jun;
12(8):761-9.
PMID: 21706006
The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity. A decisive step in this process is the polarized migration of blood neutrophils through endothelial cells...
8.
Klee P, Lamprianou S, Charollais A, Caille D, Sarro R, Cederroth M, et al.
Pediatr Res
. 2011 Apr;
70(2):142-7.
PMID: 21527868
Diabetes develops when the insulin needs of peripheral cells exceed the availability or action of the hormone. This situation results from the death of most beta-cells in type 1 diabetes,...
9.
Del Castillo F, Cohen-Salmon M, Charollais A, Caille D, Lampe P, Chavrier P, et al.
Hum Mol Genet
. 2009 Oct;
19(2):262-75.
PMID: 19864490
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the...
10.
Casimir M, Lasorsa F, Rubi B, Caille D, Palmieri F, Meda P, et al.
J Biol Chem
. 2009 Jul;
284(37):25004-14.
PMID: 19584051
The SLC25 carrier family mediates solute transport across the inner mitochondrial membrane, a process that is still poorly characterized regarding both the mechanisms and proteins implicated. This study investigated mitochondrial...