Dong-Zhi Wei
Overview
Explore the profile of Dong-Zhi Wei including associated specialties, affiliations and a list of published articles.
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Articles
141
Citations
1127
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Recent Articles
1.
Guo Q, Xu J, Li J, Tang S, Cheng Y, Gao B, et al.
Synth Syst Biotechnol
. 2024 Aug;
9(4):834-841.
PMID: 39113689
Coproporphyrin III (CP III), a natural porphyrin derivative, has extensive applications in the biomedical and material industries. has previously been engineered to highly accumulate the CP III precursor 5-aminolevulinic acid...
2.
Guo Q, Li J, Wang M, Zhao M, Zhang G, Tang S, et al.
Metab Eng
. 2024 Jul;
85:46-60.
PMID: 39019249
Heme has attracted considerable attention due to its indispensable biological roles and applications in healthcare and artificial foods. The development and utilization of edible microorganisms instead of animals to produce...
3.
Sun B, Sui H, Liu Z, Tao X, Gao B, Zhao M, et al.
Bioresour Bioprocess
. 2024 Apr;
9(1):70.
PMID: 38647553
Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient...
4.
Zhao Y, Liu Y, Song L, Yu D, Liu K, Liu K, et al.
Biotechnol Biofuels Bioprod
. 2023 Aug;
16(1):121.
PMID: 37533054
Background: Harnessing engineered Mycolicibacteria to convert cheap phytosterols into valuable steroid synthons is a basic way in the industry for the production of steroid hormones. Thus, C-19 and C-22 steroids...
5.
Dong M, Song L, Xu J, Zhu L, Xiong L, Wei D, et al.
Appl Microbiol Biotechnol
. 2023 Jul;
107(16):5257-5267.
PMID: 37405431
The engineered probiotic Escherichia coli Nissle 1917 (EcN) is expected to be employed in the diagnosis and treatment of various diseases. However, the introduced plasmids typically require antibiotics to maintain...
6.
Song L, Ke J, Luo Z, Xiong L, Dong Y, Wei D, et al.
Biotechnol Biofuels Bioprod
. 2023 Jun;
16(1):98.
PMID: 37291661
Background: The conversion of phytosterols to steroid synthons by engineered Mycolicibacteria comprises one of the core steps in the commercial production of steroid hormones. This is a complex oxidative catabolic...
7.
Du M, Zhang G, Zhu Z, Zhao Y, Gao B, Tao X, et al.
Biotechnol Biofuels Bioprod
. 2023 May;
16(1):76.
PMID: 37143155
Background: Polycyclic triterpenoids (PTs) are common in plants, and have attracted considerable interest due to their remarkable biological activities. Currently, engineering the ergosterol synthesis pathway in Saccharomyces cerevisiae is a...
8.
Ye W, Xie J, Liu Y, Wang Y, Zhang Y, Yang X, et al.
Chemistry
. 2023 Feb;
29(25):e202203530.
PMID: 36790363
An alcohol dehydrogenase LkADH was successfully engineered to exhibit improved activity and substrate tolerance for the production of (S)-2-chloro-1-(3,4-difluorophenyl)ethanol, an important precursor of ticagrelor. Five potential hotspots were identified for...
9.
Sun B, Wang F, Zhao J, Tao X, Liu M, Wei D
J Basic Microbiol
. 2022 Oct;
63(2):168-178.
PMID: 36284486
l-homoserine, a nonprotein amino acid, is used to synthesize many active substances in the industry. Here, to develop a robust l-homoserine-producing strain, Escherichia coli W3110 was used as a chassis...
10.
Liu K, Lin G, Liu K, Liu Y, Tao X, Gao B, et al.
Synth Syst Biotechnol
. 2022 Jul;
7(3):1002-1011.
PMID: 35782483
Genomic integration of genes and pathway-sized DNA cassettes is often an indispensable way to construct robust and productive microbial cell factories. For some uncommon microbial hosts, such as and species,...