Donald C Reason
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Explore the profile of Donald C Reason including associated specialties, affiliations and a list of published articles.
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13
Citations
282
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Recent Articles
1.
Vu D, Pajon R, Reason D, Granoff D
Sci Rep
. 2012 Mar;
2:341.
PMID: 22461972
Meningococcal factor H binding protein (fHbp) is an important vaccine antigen for prevention of disease caused by capsular group B strains. The protein has been sub-classified into three variant groups....
2.
Giuntini S, Beernink P, Reason D, Granoff D
PLoS One
. 2012 Mar;
7(3):e34272.
PMID: 22461909
Background: Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated bactericidal activity directly. The antibodies also can block binding...
3.
Giuntini S, Reason D, Granoff D
Infect Immun
. 2011 Nov;
80(1):187-94.
PMID: 22064712
Meningococcal vaccines containing factor H binding protein (fHbp) are in clinical development. fHbp binds human fH, which enables the meningococcus to resist complement-mediated bacteriolysis. Previously, we found that chimeric human...
4.
Giuntini S, Reason D, Granoff D
Infect Immun
. 2011 Jun;
79(9):3751-9.
PMID: 21708990
Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H...
5.
Thomson C, Little K, Reason D, Schrader J
J Immunol
. 2011 Jan;
186(4):2291-8.
PMID: 21228346
The human Ab response to many common pathogens is oligoclonal, with restricted usage of Ig V-genes. Intriguingly, the IGVK3-11 and IGVH3-30 V-genes are repeatedly paired in protective Abs against the...
6.
7.
Reason D, Ullal A, Liberato J, Sun J, Keitel W, Zhou J
Vaccine
. 2008 Jun;
26(32):4041-7.
PMID: 18565627
Protective antigen (PA) is the cell surface recognition moiety of the Bacillus anthracis A-B toxin system, and the active immunogenic component in the currently licensed human anthrax vaccine (BioThrax, or...
8.
Zhou J, Ullal A, Liberato J, Sun J, Keitel W, Reason D
Mol Immunol
. 2007 Aug;
45(2):338-47.
PMID: 17707509
The active component of the licensed human anthrax vaccine (BioThrax, or AVA) is a Bacillus anthracis toxin known as protective antigen (PA). Second generation anthrax vaccines currently under development are...
9.
Reason D, Zhou J
Biol Direct
. 2006 Sep;
1:24.
PMID: 16942619
Unlabelled: It has been suggested that codon insertion and/or deletion may represent a mechanism that, along with hypermutation, contributes to the affinity maturation of antibodies. We used repertoire cloning to...
10.
Zhou J, Lottenbach K, Barenkamp S, Reason D
Infect Immun
. 2004 May;
72(6):3505-14.
PMID: 15155658
Combinatorial cloning and expression library analysis were used to determine the expressed human antibody repertoire specific for the capsular polysaccharide (PS) of Streptococcus pneumoniae serotype 6B. Sequence analysis of 55...