Dominick Deluca
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Explore the profile of Dominick Deluca including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
92
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Recent Articles
1.
Lebsack T, Fa V, Woods C, Gruener R, Manziello A, Pecaut M, et al.
J Cell Biochem
. 2010 Mar;
110(2):372-81.
PMID: 20213684
The detrimental effects of spaceflight and simulated microgravity on the immune system have been extensively documented. We report here microarray gene expression analysis, in concert with quantitative RT-PCR, in young...
2.
White T, Chauhan V, Middlebrook A, Im J, Deluca D
Dev Comp Immunol
. 2008 Feb;
32(8):943-56.
PMID: 18295332
Natural Killer T (NKT) cells can effect both T cell development and peripheral immune responses through T(H)1/T(H)2 cytokines. Some humans with Type 1 Diabetes Mellitus (T1DM) have numerical and functional...
3.
Middlebrook A, Lebsack T, Deluca D
J Autoimmun
. 2007 Aug;
29(2-3):134-45.
PMID: 17716860
TNF-alpha is a pleiotropic cytokine that is constitutively expressed in the thymus. This cytokine has opposing effects on type 1 diabetes mellitus (T1DM) as non-obese diabetic (NOD) mice administered TNF-alpha...
4.
Woods C, Sundar K, Tessler C, Lebsack T, Grainger L, Nielsen A, et al.
J Autoimmun
. 2006 Jun;
27(1):28-37.
PMID: 16765565
Type 1 diabetes mellitus (T1DM) results from autoreactive T-cells that attack and destroy insulin producing pancreatic beta-cells. This knowledge has provided a framework for numerous efforts to prevent or mitigate...
5.
Deluca D, Basye J, Schumacher M, Lebsack T
Dev Comp Immunol
. 2006 Apr;
30(11):1084-98.
PMID: 16581123
We investigated sequential cytokine addition on human hematopoietic stem cell (HSC) differentiation in murine fetal liver (FL), fetal spleen (FS) and bone marrow (BM) organ cultures (OC). Tissues were colonized...
6.
Woods C, Banks K, Lebsack T, White T, Anderson G, Maccallum T, et al.
Dev Comp Immunol
. 2005 Mar;
29(6):565-82.
PMID: 15752552
Recently, we have shown that exposure of fetal thymus organ cultures (FTOC) to modeled microgravity (MMG) using a clinostat with a microgravity organ culture dish system (MOCDS) blocks T cell...
7.
Woods C, Banks K, Gruener R, Deluca D
FASEB J
. 2003 Jun;
17(11):1526-8.
PMID: 12824295
Using fetal thymus organ culture (FTOC), we examined the effects of spaceflight and vector-averaged gravity on T cell development. Under both conditions, the development of T cells was significantly attenuated....
8.
Kuo Y, Lucero L, Michaels J, Deluca D, Lukas R
J Neuroimmunol
. 2002 Sep;
130(1-2):140-54.
PMID: 12225896
Studies were initiated to identify nicotinic acetylcholine receptor (nAChR) subunits and subtypes expressed in the developing immune system and cell types on which nAChR are expressed. Reported here are reverse...
9.
Middlebrook A, Martina C, Chang Y, Lukas R, Deluca D
J Immunol
. 2002 Sep;
169(6):2915-24.
PMID: 12218105
There is evidence for both physiological functions of the natural neurotransmitter, acetylcholine, and pharmacological actions of the plant alkaloid, nicotine, on the development and function of the immune system. The...
10.
Christianson S, Greiner D, Deluca D, Leif J, Phillips N, Hayes S, et al.
J Autoimmun
. 2002 Mar;
18(2):119-30.
PMID: 11908944
Defects in the gene that encodes SHP-1 protein tyrosine phosphatase result in multiple hematopoietic abnormalities and generalized autoimmunity in viable motheaten (me(v)) mice. These mice also exhibit early thymic involution...