Dominic J Vita
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Explore the profile of Dominic J Vita including associated specialties, affiliations and a list of published articles.
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10
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99
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Recent Articles
1.
Vita D, Orsi F, Stanko N, Clark N, Tiriac A
Nat Commun
. 2024 Jun;
15(1):4829.
PMID: 38844438
Orientation or axial selectivity, the property of neurons in the visual system to respond preferentially to certain angles of visual stimuli, plays a pivotal role in our understanding of visual...
2.
Nelson N, Vita D, Broadie K
Sci Rep
. 2024 Apr;
14(1):9110.
PMID: 38643298
Critical periods are temporally-restricted, early-life windows when sensory experience remodels synaptic connectivity to optimize environmental input. In the Drosophila juvenile brain, critical period experience drives synapse elimination, which is transiently...
3.
Vita D, Orsi F, Stanko N, Clark N, Tiriac A
bioRxiv
. 2024 Apr;
PMID: 38585937
One Sentence Summary: Development and organization of retinal orientation selectivity.
4.
Leahy S, Vita D, Broadie K
J Neurosci
. 2024 Mar;
44(17).
PMID: 38471782
Cytoplasmic protein tyrosine phosphatase nonreceptor type 11 (PTPN11) and homolog Corkscrew (Csw) regulate the mitogen-activated protein kinase (MAPK) pathway via a conserved autoinhibitory mechanism. Disease-causing loss-of-function (LoF) and gain-of-function (GoF)...
5.
Leahy S, Song C, Vita D, Broadie K
PLoS Biol
. 2023 Jan;
21(1):e3001969.
PMID: 36701299
Noonan syndrome (NS) and NS with multiple lentigines (NSML) cognitive dysfunction are linked to SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) gain-of-function (GoF) and loss-of-function (LoF), respectively. In Drosophila disease models,...
6.
Vita D, Meier C, Broadie K
Nat Commun
. 2021 Feb;
12(1):1160.
PMID: 33608547
Glia engulf and phagocytose neurons during neural circuit developmental remodeling. Disrupting this pruning process contributes to Fragile X syndrome (FXS), a leading cause of intellectual disability and autism spectrum disorder...
7.
Kopke D, Leahy S, Vita D, Lima S, Newman Z, Broadie K
eNeuro
. 2020 Feb;
7(2).
PMID: 32024666
The first Wnt signaling ligand discovered, Wingless [Wg (Wnt1 in mammals)], plays critical roles in neuromuscular junction (NMJ) development, regulating synaptic architecture, and function. Heparan sulfate proteoglycans (HSPGs), consisting of...
8.
Golovin R, Vest J, Vita D, Broadie K
J Neurosci
. 2019 Feb;
39(16):2995-3012.
PMID: 30755492
Critical periods are windows of development when the environment has a pronounced effect on brain circuitry. Models of neurodevelopmental disorders, including autism spectrum disorders, intellectual disabilities, and schizophrenia, are linked...
9.
Vita D, Broadie K
Sci Rep
. 2017 Aug;
7(1):8683.
PMID: 28819289
The leading cause of heritable intellectual disability (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-binding translational suppressor Fragile X Mental Retardation...
10.
Doll C, Vita D, Broadie K
Curr Biol
. 2017 Aug;
27(15):2318-2330.e3.
PMID: 28756946
Activity-dependent synaptic remodeling occurs during early-use critical periods, when naive juveniles experience sensory input. Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor mechanism based on...