Dolores Siedlecki-Wullich
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Explore the profile of Dolores Siedlecki-Wullich including associated specialties, affiliations and a list of published articles.
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8
Citations
105
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Recent Articles
1.
Gomez-Murcia V, Launay A, Carvalho K, Burgard A, Meriaux C, Caillierez R, et al.
Brain
. 2024 Jul;
147(8):2691-2705.
PMID: 38964748
Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine targets, by neurons is thought to be involved in the development of synaptic and memory deficits in Alzheimer's...
2.
Saha O, Melo de Farias A, Pelletier A, Siedlecki-Wullich D, Landeira B, Gadaut J, et al.
Mol Psychiatry
. 2024 Mar;
29(9):2634-2646.
PMID: 38514804
Bridging Integrator 1 (BIN1) is the second most important Alzheimer's disease (AD) risk gene, but its physiological roles in neurons and its contribution to brain pathology remain largely elusive. In...
3.
Lefebvre C, Vreulx A, Dumortier C, Begard S, Gelle C, Siedlecki-Wullich D, et al.
ACS Biomater Sci Eng
. 2024 Feb;
10(3):1856-1868.
PMID: 38385618
Alzheimer's disease (AD) is a neurodegenerative disease and the most frequent cause of dementia. It is characterized by the accumulation in the brain of two pathological protein aggregates: amyloid-β peptides...
4.
Coulon A, Siedlecki-Wullich D, Najdek C, Gelle C, Ayral A, Demiautte F, et al.
Curr Protoc
. 2023 Oct;
3(10):e904.
PMID: 37882787
The synapse, which represents the structural and functional basis of neuronal communication, is one of the first elements affected in several neurodegenerative diseases. To better understand the potential role of...
5.
Catala-Solsona J, Lituma P, Lutzu S, Siedlecki-Wullich D, Fabregas-Ordonez C, Minano-Molina A, et al.
J Neurosci
. 2023 Mar;
43(17):3028-3041.
PMID: 36931707
Transcription factors have a pivotal role in synaptic plasticity and the associated modification of neuronal networks required for memory formation and consolidation. The nuclear receptors subfamily 4 group A (Nr4a)...
6.
Siedlecki-Wullich D, Minano-Molina A, Rodriguez-Alvarez J
Cells
. 2021 Jan;
10(1).
PMID: 33435363
Pathogenic processes underlying Alzheimer's disease (AD) affect synaptic function from initial asymptomatic stages, long time before the onset of cognitive decline and neurodegeneration. Therefore, reliable biomarkers enabling early AD diagnosis...
7.
Cheng W, Siedlecki-Wullich D, Catala-Solsona J, Fabregas C, Fado R, Casals N, et al.
eNeuro
. 2020 Mar;
7(2).
PMID: 32205379
The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during long-term potentiation (LTP) and...
8.
Siedlecki-Wullich D, Catala-Solsona J, Fabregas C, Hernandez I, Clarimon J, Lleo A, et al.
Alzheimers Res Ther
. 2019 May;
11(1):46.
PMID: 31092279
Background: Several evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer's disease (AD) preceding neuronal loss and the classical AD pathological hallmarks. Nowadays, there is an...