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Dmytro Ustianenko

Explore the profile of Dmytro Ustianenko including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 402
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Recent Articles
1.
Recinos Y, Ustianenko D, Yeh Y, Wang X, Jacko M, Yesantharao L, et al.
Nat Commun . 2024 May; 15(1):3839. PMID: 38714659
Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides (ASOs). However, determining promising targets is hampered by the challenge of...
2.
Feng H, Lu X, Maji S, Liu L, Ustianenko D, Rudnick N, et al.
Nat Commun . 2024 Mar; 15(1):2279. PMID: 38480694
UV-crosslinking of protein and RNA in direct contacts has been widely used to study protein-RNA complexes while our understanding of the photo-crosslinking mechanisms remains poor. This knowledge gap is due...
3.
Recinos Y, Ustianenko D, Yeh Y, Wang X, Jacko M, Yesantharao L, et al.
bioRxiv . 2023 Sep; PMID: 37662340
Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides (ASOs). However, determining promising targets is impeded by the challenge of...
4.
Ustianenko D, McKenzie M, Zhang C
Mol Cell . 2020 Mar; 77(6):1155-1156. PMID: 32200794
In this issue of Molecular Cell, Gonatopoulos-Pournatzis et al. (2020) report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic protein translation. Autism-associated disruption of this exon results...
5.
Ustianenko D, Chiu H, Treiber T, Weyn-Vanhentenryck S, Treiber N, Meister G, et al.
Mol Cell . 2018 Jul; 71(2):271-283.e5. PMID: 30029005
LIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits the biogenesis of let-7 microRNAs to regulate development and influence disease states. However, the mechanisms of let-7 suppression remain poorly understood...
6.
Weyn-Vanhentenryck S, Feng H, Ustianenko D, Duffie R, Yan Q, Jacko M, et al.
Nat Commun . 2018 Jun; 9(1):2189. PMID: 29875359
Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated during neurodevelopment. However, the precise timing of developmental splicing switches and the underlying regulatory mechanisms...
7.
Ustianenko D, Weyn-Vanhentenryck S, Zhang C
Wiley Interdiscip Rev RNA . 2017 Feb; 8(4). PMID: 28188674
The importance of RNA splicing in numerous cellular processes is well established. However, an underappreciated aspect is the ability of the spliceosome to recognize a set of very small (3-30...
8.
Ustianenko D, Pasulka J, Feketova Z, Bednarik L, Zigackova D, Fortova A, et al.
EMBO J . 2016 Sep; 35(20):2179-2191. PMID: 27647875
Uridylation of various cellular RNA species at the 3' end has been generally linked to RNA degradation. In mammals, uridylated pre-let-7 miRNAs and mRNAs are targeted by the 3' to...
9.
Ustianenko D, Hrossova D, Potesil D, Chalupnikova K, Hrazdilova K, Pachernik J, et al.
RNA . 2013 Oct; 19(12):1632-8. PMID: 24141620
The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3' uridylation via LIN28A-TUT4/7...