Dirk Wohlleber
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Explore the profile of Dirk Wohlleber including associated specialties, affiliations and a list of published articles.
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42
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1763
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Recent Articles
1.
Seitz S, Dreyer T, Stange C, Steiger K, Wohlleber D, Anton M, et al.
Neoplasia
. 2025 Jan;
60:101130.
PMID: 39862711
T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors. The chemokine CX3CL1 recruits...
2.
Wohlleber D, Knolle P
Z Gastroenterol
. 2025 Jan;
63(1):65-72.
PMID: 39793603
The liver is an organ bearing important metabolic and immune functions. Hepatocytes are the main metabolically active cells of the liver and are the target of infection by hepatotropic viruses....
3.
Heim K, Sagar , Sogukpinar O, Llewellyn-Lacey S, Price D, Emmerich F, et al.
Nat Immunol
. 2024 Aug;
25(9):1650-1662.
PMID: 39198634
Hepatitis B virus (HBV)-specific CD8 T cells play a dominant role during acute-resolving HBV infection but are functionally impaired during chronic HBV infection in humans. These functional deficits have been...
4.
Bosch M, Kallin N, Donakonda S, Zhang J, Wintersteller H, Hegenbarth S, et al.
Nature
. 2024 Jul;
631(8022):867-875.
PMID: 38987588
Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes. Here...
5.
Winkler F, Hipp A, Ramirez C, Martin B, Villa M, Neuwirt E, et al.
Gut
. 2023 Aug;
72(10):1971-1984.
PMID: 37541771
Objective: Exhausted T cells with limited effector function are enriched in chronic hepatitis B and C virus (HBV and HCV) infection. Metabolic regulation contributes to exhaustion, but it remains unclear...
6.
Meiser P, Knolle M, Hirschberger A, de Almeida G, Bayerl F, Lacher S, et al.
Cancer Cell
. 2023 Jul;
41(8):1498-1515.e10.
PMID: 37451271
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cancer immunity is poorly understood. Here, we use imaging-based deep...
7.
Bayerl F, Meiser P, Donakonda S, Hirschberger A, Lacher S, Pedde A, et al.
Immunity
. 2023 Jun;
56(6):1341-1358.e11.
PMID: 37315536
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors, but it is poorly...
8.
Esser K, Cheng X, Wettengel J, Lucifora J, Hansen-Palmus L, Austen K, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Apr;
16(2):201-221.
PMID: 37054914
Background & Aims: A single hepatitis B virus (HBV) particle is sufficient to establish chronic infection of the liver after intravenous injection, suggesting that the virus targets hepatocytes via a...
9.
Yin Y, Sichler A, Ecker J, Laschinger M, Liebisch G, Horing M, et al.
J Hepatol
. 2023 Jan;
78(4):820-835.
PMID: 36681162
Background & Aims: Hepatocyte growth and proliferation depends on membrane phospholipid biosynthesis. Short-chain fatty acids (SCFAs) generated by bacterial fermentation, delivered through the gut-liver axis, significantly contribute to lipid biosynthesis....
10.
Brugger M, Laschinger M, Lampl S, Schneider A, Manske K, Esfandyari D, et al.
JHEP Rep
. 2022 Apr;
4(5):100465.
PMID: 35462860
Background & Aims: Increased sensitivity towards tumor necrosis factor (TNF)-induced cell death in virus-infected hepatocytes has revealed a so far unrecognized hepatocyte-intrinsic antiviral immune surveillance mechanism, for which no or...