Dirk-Jan Kleinjan
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Explore the profile of Dirk-Jan Kleinjan including associated specialties, affiliations and a list of published articles.
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8
Citations
450
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Recent Articles
1.
Bhaskar H, Gidden Z, Virdi G, Kleinjan D, Rosser S, Gandhi S, et al.
Protein Sci
. 2025 Jan;
34(2):e70008.
PMID: 39865341
Super-resolution microscopy has revolutionized biological imaging, enabling the visualization of structures at the nanometer length scale. Its application in live cells, however, has remained challenging. To address this, we adapted...
2.
Boni R, Blackburn E, Kleinjan D, Jonaitis M, Hewitt-Harris F, Murdoch M, et al.
J Struct Biol
. 2023 May;
215(3):107981.
PMID: 37245604
Biomaterials for tissue regeneration must mimic the biophysical properties of the native physiological environment. A protein engineering approach allows the generation of protein hydrogels with specific and customised biophysical properties...
3.
Bhaskar H, Kleinjan D, Oi C, Gidden Z, Rosser S, Horrocks M, et al.
Protein Sci
. 2022 Dec;
32(2):e4558.
PMID: 36585831
We present direct-LIVE-PAINT, an easy-to-implement approach for the nanoscopic imaging of protein structures in live cells using labeled binding peptides. We demonstrate the feasibility of direct-LIVE-PAINT with an actin-binding peptide...
4.
Donaldson J, Kleinjan D, Rosser S
Curr Opin Biotechnol
. 2022 Oct;
78:102806.
PMID: 36194920
Fed-batch culture of Chinese hamster ovary (CHO) cells remains the most commonly used method for producing biopharmaceuticals. Static CHO cell-line engineering approaches have incrementally improved productivity, growth and product quality...
5.
Dora N, Manuel M, Kleinjan D, Price D, Collinson J, Hill R, et al.
BMC Res Notes
. 2018 Oct;
11(1):705.
PMID: 30290846
Objective: The corneas of heterozygous Pax6 mice develop abnormally and deteriorate further after birth but it is not known whether the postnatal deterioration is predetermined by abnormal development. Our objective...
6.
A long range distal enhancer controls temporal fine-tuning of PAX6 expression in neuronal precursors
Lacomme M, Medevielle F, Bourbon H, Thierion E, Kleinjan D, Roussat M, et al.
Dev Biol
. 2018 Feb;
436(2):94-107.
PMID: 29486153
Proper embryonic development relies on a tight control of spatial and temporal gene expression profiles in a highly regulated manner. One good example is the ON/OFF switching of the transcription...
7.
Kleinjan D, Coutinho P
Brief Funct Genomic Proteomic
. 2009 Jul;
8(4):317-32.
PMID: 19596743
The spatiotemporally and quantitatively correct activity of a gene requires the presence of intact coding sequence as well as properly functioning regulatory control. One of the great challenges of the...
8.
Sansom S, Griffiths D, Faedo A, Kleinjan D, Ruan Y, Smith J, et al.
PLoS Genet
. 2009 Jun;
5(6):e1000511.
PMID: 19521500
Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6...
9.
Benko S, Fantes J, Amiel J, Kleinjan D, Thomas S, Ramsay J, et al.
Nat Genet
. 2009 Feb;
41(3):359-64.
PMID: 19234473
Pierre Robin sequence (PRS) is an important subgroup of cleft palate. We report several lines of evidence for the existence of a 17q24 locus underlying PRS, including linkage analysis results,...