Dion H Zappe
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Explore the profile of Dion H Zappe including associated specialties, affiliations and a list of published articles.
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25
Citations
298
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Recent Articles
11.
Williams B, Cockcroft J, Kario K, Zappe D, Cardenas P, Hester A, et al.
BMJ Open
. 2014 Feb;
4(2):e004254.
PMID: 24496699
Introduction: Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness. LCZ696, a first-in-class angiotensin receptor...
12.
Hayoz D, Zappe D, Meyer M, Baek I, Kandra A, Joly M, et al.
J Clin Hypertens (Greenwich)
. 2012 Nov;
14(11):773-8.
PMID: 23126349
Postmenopausal women are at greater risk for hypertension-related cardiovascular disease. Antihypertensive therapy may help alleviate arterial stiffness that represents a potential modifiable risk factor of hypertension. This randomized controlled study...
13.
Weber M, Julius S, Kjeldsen S, Jia Y, Brunner H, Zappe D, et al.
J Hypertens
. 2012 Sep;
30(11):2213-22.
PMID: 23011525
Objectives: To determine whether blood pressure (BP) control in hypertensive patients achieved with combination drug therapy provides the same cardiovascular benefits as with single-agent therapy. Background: Drug combinations, most often...
14.
Deedwania P, Zappe D, Egan B, Purkayastha D, Samuel R, Sowers J
J Clin Hypertens (Greenwich)
. 2012 Jul;
14(7):415-21.
PMID: 22747613
The authors previously reported that addition of valsartan ameliorated the negative metabolic effects of hydrochlorothiazide in obese hypertensive patients through an enhanced postprandial insulin response. In this secondary analysis, the...
15.
Weintraub H, Duprez D, Cushman W, Zappe D, Purkayastha D, Samuel R, et al.
Cardiovasc Drugs Ther
. 2012 Feb;
26(2):145-55.
PMID: 22311004
Purpose: Renin profiling has been proposed as a method to guide antihypertensive drug selection. This prespecified post-hoc analysis examined the influence of baseline plasma renin activity (PRA) on blood pressure...
16.
Ofili E, Zappe D, Purkayastha D, Samuel R, Sowers J
Am J Ther
. 2012 Jan;
20(1):2-12.
PMID: 22248871
A clinical trial showed comparable blood pressure (BP) lowering by valsartan/hydrochlorothiazide and amlodipine/hydrochlorothiazide in obese hypertensive patients. Relative to amlodipine/hydrochlorothiazide, valsartan/hydrochlorothiazide reduced the hyperglycemic response to glucose challenge. An objective...
17.
Raij L, Egan B, Zappe D, Purkayastha D, Samuel R, Sowers J
J Clin Hypertens (Greenwich)
. 2011 Oct;
13(10):731-8.
PMID: 21974760
The authors evaluated the blood pressure (BP)-lowering effects of combination valsartan/hydrochlorothiazide (HCTZ) vs. amlodipine/HCTZ in a 16-week, double-blind, randomized, forced-titration study and ambulatory BP monitoring (ABPM) substudy involving centrally obese...
18.
Weir M, Hollenberg N, Remuzzi G, Zappe D, Meng X, Parving H
J Hypertens
. 2011 Aug;
29(10):2031-7.
PMID: 21841500
Objective: In patients with type 2 diabetes mellitus (T2DM), blocking of the renin-angiotensin-aldosterone system (RAAS) has demonstrated efficacy in lowering blood pressure (BP) and urinary albumin excretion rate (UAER). Nonetheless,...
19.
Anand I, Deswal A, Kereiakes D, Purkayastha D, Zappe D
Vasc Health Risk Manag
. 2010 Aug;
6:449-55.
PMID: 20730060
Background: The safety of once-daily (qd) dosing of valsartan in heart failure (HF) patients is not known. Hypothesis: This 10-week, double-blind trial examined the relative safety and efficacy of valsartan...
20.
Angiotensin receptor blocker/diuretic combination preserves insulin responses in obese hypertensives
Sowers J, Raij L, Jialal I, Egan B, Ofili E, Samuel R, et al.
J Hypertens
. 2010 May;
28(8):1761-9.
PMID: 20498618
Background: Thiazide diuretics can impair glucose metabolism and increase new-onset diabetes. Adding an angiotensin receptor blocker to diuretics may protect against these metabolic effects; however, the mechanism of this protection...