Dina Buitrago Silva
Overview
Explore the profile of Dina Buitrago Silva including associated specialties, affiliations and a list of published articles.
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5
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10
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Recent Articles
1.
Silva D, Trinidad M, Ljungdahl A, Revalde J, Berguig G, Wallace W, et al.
Am J Hum Genet
. 2024 May;
111(6):1222-1238.
PMID: 38781976
Heterozygous variants in SLC6A1, encoding the GAT-1 GABA transporter, are associated with seizures, developmental delay, and autism. The majority of affected individuals carry missense variants, many of which are recurrent...
2.
Yee S, Macdonald C, Mitrovic D, Zhou X, Koleske M, Yang J, et al.
Mol Cell
. 2024 May;
84(10):1932-1947.e10.
PMID: 38703769
Mutations in transporters can impact an individual's response to drugs and cause many diseases. Few variants in transporters have been evaluated for their functional impact. Here, we combine saturation mutagenesis...
3.
Yee S, Macdonald C, Mitrovic D, Zhou X, Koleske M, Yang J, et al.
bioRxiv
. 2023 Jun;
PMID: 37333090
Membrane transporters play a fundamental role in the tissue distribution of endogenous compounds and xenobiotics and are major determinants of efficacy and side effects profiles. Polymorphisms within these drug transporters...
4.
Azimi M, Yee S, Riselli A, Silva D, Giacomini C, Giacomini K, et al.
J Vet Pharmacol Ther
. 2023 May;
46(6):401-412.
PMID: 37198956
The ATP-binding cassette transporter P-glycoprotein (P-gp) limits the oral bioavailability of many drugs. Although P-gp has been well studied in humans and mice, little is known about the substrate specificities...
5.
Hutchinson K, Silva D, Bohlke J, Clausen C, Thomas A, Bonomi M, et al.
Biophys J
. 2022 Nov;
121(23):4476-4491.
PMID: 36369754
The human L-type amino acid transporter 1 (LAT1; SLC7A5) is a membrane transporter of amino acids, thyroid hormones, and drugs such as the Parkinson's disease drug levodopa (L-Dopa). LAT1 is...