Dimitry Ofengeim
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Explore the profile of Dimitry Ofengeim including associated specialties, affiliations and a list of published articles.
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38
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3325
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Recent Articles
1.
Gruber R, Wirak G, Blazier A, Lee L, Dufault M, Hagan N, et al.
Nat Commun
. 2024 Nov;
15(1):10116.
PMID: 39578444
Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability accumulation in multiple sclerosis (MS) but has not been...
2.
Cheong A, Craciun F, Husson H, Gans J, Escobedo J, Chang Y, et al.
Commun Biol
. 2024 Aug;
7(1):932.
PMID: 39095617
While significant advances have been made in understanding renal pathophysiology, less is known about the role of glycosphingolipid (GSL) metabolism in driving organ dysfunction. Here, we used a small molecule...
3.
Turner T, Brun P, Gruber R, Ofengeim D
Drugs R D
. 2024 Jul;
24(2):263-274.
PMID: 38965189
Background And Objectives: Tolebrutinib is a covalent BTK inhibitor designed and selected for potency and CNS exposure to optimize impact on BTK-dependent signaling in CNS-resident cells. We applied a translational...
4.
Du Z, Lessard S, Iyyanki T, Chao M, Hammond T, Ofengeim D, et al.
HGG Adv
. 2024 Jun;
5(3):100317.
PMID: 38851890
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, immune-mediated disorder in which an aberrant immune response causes demyelination and axonal damage of the peripheral nerves. Genetic contribution to CIDP is...
5.
Kim H, Urquhart R, Pontarelli F, Jover-Mengual T, Ofengeim D, Hwang J
STAR Protoc
. 2024 Jan;
4(4):102630.
PMID: 38264871
Global cerebral ischemia occurs when blood flow to the entire brain is transiently blocked, which results in delayed neurologic deficits. Here, we present a protocol for performing the four-vessel occlusion...
6.
Yuan J, Ofengeim D
Nat Rev Mol Cell Biol
. 2023 Dec;
25(5):379-395.
PMID: 38110635
Regulated cell death mediated by dedicated molecular machines, known as programmed cell death, plays important roles in health and disease. Apoptosis, necroptosis and pyroptosis are three such programmed cell death...
7.
Hincelin-Mery A, Nicolas X, Cantalloube C, Pomponio R, Lewanczyk P, Benamor M, et al.
Clin Transl Sci
. 2023 Nov;
17(1):e13690.
PMID: 38010108
SAR443820 (DNL788) is a selective, orally bioavailable, brain penetrant inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1). This phase I first-in-human healthy participant study (NCT05795907) was comprised of three parts:...
8.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
9.
Ryan S, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M, et al.
Nat Neurosci
. 2022 Dec;
26(1):12-26.
PMID: 36536241
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and...
10.
Wenzel J, Lampe J, Muller-Fielitz H, Schuster R, Zille M, Muller K, et al.
Nat Neurosci
. 2021 Oct;
24(11):1522-1533.
PMID: 34675436
Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms...