Dimitris V Manatakis
Overview
Explore the profile of Dimitris V Manatakis including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
584
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Recent Articles
1.
Kerns J, Belgur C, Kanellias M, Manatakis D, Barrile R, Tien-Street W, et al.
Bio Protoc
. 2023 Feb;
13(1).
PMID: 36789090
Traditional drug safety assessments often fail to predict complications in humans, especially when the drug targets the immune system. Rodent-based preclinical animal models are often ill-suited for predicting immunotherapy-mediated adverse...
2.
Ewart L, Apostolou A, Briggs S, Carman C, Chaff J, Heng A, et al.
Commun Med (Lond)
. 2023 Feb;
3(1):16.
PMID: 36732600
No abstract available.
3.
Ewart L, Apostolou A, Briggs S, Carman C, Chaff J, Heng A, et al.
Commun Med (Lond)
. 2023 Jan;
3(1):7.
PMID: 36635369
No abstract available.
4.
Ewart L, Apostolou A, Briggs S, Carman C, Chaff J, Heng A, et al.
Commun Med (Lond)
. 2022 Dec;
2(1):154.
PMID: 36473994
Background: Conventional preclinical models often miss drug toxicities, meaning the harm these drugs pose to humans is only realized in clinical trials or when they make it to market. This...
5.
Pediaditakis I, Kodella K, Manatakis D, Le C, Barthakur S, Sorets A, et al.
iScience
. 2022 Aug;
25(8):104813.
PMID: 35982785
Species differences in brain and blood-brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases. Here, we present...
6.
Pediaditakis I, Kodella K, Manatakis D, Le C, Hinojosa C, Tien-Street W, et al.
Nat Commun
. 2021 Oct;
12(1):5907.
PMID: 34625559
Parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical evidence and in vitro...
7.
Kerns S, Belgur C, Petropolis D, Kanellias M, Barrile R, Sam J, et al.
Elife
. 2021 Aug;
10.
PMID: 34378534
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two human Organs-on-Chips to...
8.
Manatakis D, VanDevender A, Manolakos E
Bioinformatics
. 2021 Aug;
37(16):2512.
PMID: 34378020
No abstract available.
9.
Nawroth J, Petropolis D, Manatakis D, Maulana T, Burchett G, Schlunder K, et al.
Cell Rep
. 2021 Jul;
36(3):109393.
PMID: 34289365
Alcohol-associated liver disease (ALD) is a global health issue and leads to progressive liver injury, comorbidities, and increased mortality. Human-relevant preclinical models of ALD are urgently needed. Here, we leverage...
10.
Apostolou A, Panchakshari R, Banerjee A, Manatakis D, Paraskevopoulou M, Luc R, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Jul;
12(5):1719-1741.
PMID: 34284165
Background & Aims: The limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to be harnessed...