Dimitrios C Ladakis
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Explore the profile of Dimitrios C Ladakis including associated specialties, affiliations and a list of published articles.
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13
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13
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Recent Articles
1.
Ladakis D, Harrison K, Smith M, Solem K, Gadani S, Jank L, et al.
Med
. 2024 Oct;
6(3):100522.
PMID: 39447576
Background: Bile acid metabolism is altered in multiple sclerosis (MS) and tauroursodeoxycholic acid (TUDCA) supplementation ameliorated disease in mouse models of MS. Methods: Global metabolomics was performed in an observational...
2.
Siavoshi F, Ladakis D, Muller A, Nourbakhsh B, Bhargava P
Ann Clin Transl Neurol
. 2024 Aug;
11(9):2485-2498.
PMID: 39185939
Background: Circulating metabolite levels are altered in multiple sclerosis (MS) and are associated with MS severity. However, how metabolic profiles shift following highly efficacious therapies, like ocrelizumab remains unclear. Objective:...
3.
Said Y, Ladakis D, Lefelar J, Khazen J, Gould J, Fitzgerald K, et al.
Mult Scler J Exp Transl Clin
. 2024 Aug;
10(3):20552173241274605.
PMID: 39185445
Background: There is a paucity of studies examining quality of life (QoL) in people with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods: A cross-sectional, online, self-administered survey was distributed. Data...
4.
Jank L, Kesharwani A, Ryu T, Joshi D, Ladakis D, Smith M, et al.
J Neuroinflammation
. 2024 Jun;
21(1):154.
PMID: 38851724
Extracellular vesicles (EVs) are released by all cells, can cross the blood-brain barrier, and have been shown to play an important role in cellular communication, substance shuttling, and immune modulation....
5.
Ladakis D, Vreones M, Blommer J, Harrison K, Smith M, Vasileiou E, et al.
Neurol Neuroimmunol Neuroinflamm
. 2024 May;
11(4):e200257.
PMID: 38754047
Objectives: To assess whether the rate of change in synaptic proteins isolated from neuronally enriched extracellular vesicles (NEVs) is associated with brain and retinal atrophy in people with multiple sclerosis...
6.
Ladakis D, Pedrini E, Reyes-Mantilla M, Sanjayan M, Smith M, Fitzgerald K, et al.
Neurol Neuroimmunol Neuroinflamm
. 2024 Mar;
11(3):e200219.
PMID: 38547430
Background And Objectives: People with multiple sclerosis (MS) have a dysregulated circulating metabolome, but the metabolome of MS brain lesions has not been studied. The aims of this study were...
7.
Ladakis D, Harrison K, Smith M, Solem K, Gadani S, Jank L, et al.
medRxiv
. 2024 Jan;
PMID: 38293182
Background: Bile acid metabolism is altered in multiple sclerosis (MS) and tauroursodeoxycholic acid (TUDCA) supplementation ameliorated disease in mouse models of MS. Methods: Global metabolomics was performed in an observational...
8.
Ladakis D, Reyes-Mantilla M, Gadani S, Mace J, Dominguez-Penuela S, Appiah M, et al.
Mult Scler
. 2023 Nov;
30(1):35-43.
PMID: 37982154
Background: Macrophage migration inhibitory factor (MIF) is a cytokine linked to multiple sclerosis (MS) progression that is thought to be inhibited by ibudilast. SPRINT-MS was a phase 2 placebo-controlled trial...
9.
Virupakshaiah A, Ladakis D, Nourbakhsh B, Bhargava P, Dilwali S, Schoeps V, et al.
Mult Scler
. 2023 May;
29(8):936-944.
PMID: 37199529
Background: The circulating metabolome is altered in multiple sclerosis (MS), but its prognostic capabilities have not been extensively explored. Lipid metabolites might be of particular interest due to their multiple...
10.
Ladakis D, Bhargava P
CNS Drugs
. 2023 Jan;
37(2):117-132.
PMID: 36690786
It has now been established that a perturbation in gut microbiome composition exists in multiple sclerosis (MS) and its interplay with the immune system and brain could potentially contribute to...