Diana Merino
Overview
Explore the profile of Diana Merino including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
349
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0
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Recent Articles
1.
Connors D, Allen J, Alvarez J, Boyle J, Cristofanilli M, Hiller C, et al.
Crit Rev Oncol Hematol
. 2020 Oct;
156:103112.
PMID: 33035734
The promise of precision medicine as a model to customize health care to the individual patient is heavily dependent upon new genetic tools to classify and characterize diseases and their...
2.
Shea M, Audibert C, Stewart M, Gentile B, Merino D, Hong A, et al.
J Patient Exp
. 2020 Aug;
7(2):217-224.
PMID: 32851143
Background: Despite increased incorporation of patient-reported outcome (PRO) measures into clinical trials, information generated from PROs remains largely absent from drug labeling and electronic health records, giving rise to concerns...
3.
Stenzinger A, Endris V, Budczies J, Merkelbach-Bruse S, Kazdal D, Dietmaier W, et al.
J Thorac Oncol
. 2020 Mar;
15(7):1177-1189.
PMID: 32119917
Introduction: Tumor mutational burden (TMB) is a quantitative assessment of the number of somatic mutations within a tumor genome. Immunotherapy benefit has been associated with TMB assessed by whole-exome sequencing...
4.
Samuel N, Wilson G, Lemire M, Said B, Lou Y, Li W, et al.
J Clin Oncol
. 2016 Aug;
34(30):3697-3704.
PMID: 27551116
Purpose: Although the link between mutant TP53 and human cancer is unequivocal, a significant knowledge gap exists in clinically actionable molecular targets in Li-Fraumeni syndrome (LFS), a highly penetrant cancer...
5.
Tong Y, Merino D, Nimmervoll B, Gupta K, Wang Y, Finkelstein D, et al.
Cancer Cell
. 2015 May;
27(5):712-27.
PMID: 25965574
Choroid plexus carcinomas (CPCs) are poorly understood and frequently lethal brain tumors with few treatment options. Using a mouse model of the disease and a large cohort of human CPCs,...
6.
Mangerel J, Price A, Castelo-Branco P, Brzezinski J, Buczkowicz P, Rakopoulos P, et al.
Acta Neuropathol
. 2014 Oct;
128(6):853-62.
PMID: 25315281
Although telomeres are maintained in most cancers by telomerase activation, a subset of tumors utilize alternative lengthening of telomeres (ALT) to sustain self-renewal capacity. In order to study the prevalence...
7.
Merino D, Malkin D
Subcell Biochem
. 2014 Sep;
85:1-16.
PMID: 25201186
The roles of p53 as "guardian of the genome" are extensive, encompassing regulation of the cell cycle, DNA repair, apoptosis, cellular metabolism, and senescence - ultimately steering cells through a...
8.
Castelo-Branco P, Choufani S, Mack S, Gallagher D, Zhang C, Lipman T, et al.
Lancet Oncol
. 2013 Apr;
14(6):534-42.
PMID: 23598174
Background: Identification of robust biomarkers of malignancy and methods to establish disease progression is a major goal in paediatric neuro-oncology. We investigated whether methylation of the TERT promoter can be...