Diana Hatoum
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Explore the profile of Diana Hatoum including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
173
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Recent Articles
1.
Chen H, Haddadi N, Zhu X, Hatoum D, Chen S, Nassif N, et al.
J Oncol
. 2022 Dec;
2022:2250407.
PMID: 36532885
Background: Overexpression of sphingosine kinase 1 (SphK1) is casually associated with many types of cancer, and inhibitors of SphK1 sensitize tumors to chemotherapy. SphK1 is expressed as two major isoforms,...
2.
Moulder D, Hatoum D, Tay E, Lin Y, McGowan E
Cancers (Basel)
. 2018 Jun;
10(6).
PMID: 29890631
Cancer research has been heavily geared towards genomic events in the development and progression of cancer. In contrast, metabolic regulation, such as aberrant metabolism in cancer, is poorly understood. Alteration...
3.
McGowan E, Lin Y, Hatoum D
Cancers (Basel)
. 2018 Jun;
10(6).
PMID: 29857525
"", , Most breast cancers arise from the milk-producing cells that are characterized by aberrant cellular, molecular, and epigenetic translation. By understanding the underlying molecular disruptions leading to the origin...
4.
Hatoum D, Haddadi N, Lin Y, Nassif N, McGowan E
Oncotarget
. 2017 Apr;
8(22):36898-36929.
PMID: 28415564
The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations in SphKs, that may justify abnormal...
5.
Hatoum D, Yagoub D, Ahadi A, Nassif N, McGowan E
PLoS One
. 2017 Jan;
12(1):e0169925.
PMID: 28068434
The annexin family and S100A associated proteins are important regulators of diverse calcium-dependent cellular processes including cell division, growth regulation and apoptosis. Dysfunction of individual annexin and S100A proteins is...
6.
Hatoum D, McGowan E
Biomed Res Int
. 2015 Apr;
2015:548436.
PMID: 25866793
There is substantial epidemiological evidence pointing to an increased incidence of breast cancer and morbidity in obese, prediabetic, and diabetic patients. In vitro studies strongly support metformin, a diabetic medication,...
7.
Yagoub D, Wilkins M, Lay A, Kaczorowski D, Hatoum D, Bajan S, et al.
Mol Endocrinol
. 2014 Sep;
28(11):1899-915.
PMID: 25216046
Sphingosine kinase 1 (SK1) is a signaling enzyme that catalyzes the formation of sphingosine-1-phosphate. Overexpression of SK1 is causally associated with breast cancer progression and resistance to therapy. SK1 inhibitors...