Devikala Gurusamy
Overview
Explore the profile of Devikala Gurusamy including associated specialties, affiliations and a list of published articles.
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22
Citations
955
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Recent Articles
1.
Leko V, Groh E, Levi S, Copeland A, White B, Gasmi B, et al.
J Immunother Cancer
. 2025 Jan;
13(1.
PMID: 39800378
Background: The use of tumor-infiltrating T lymphocytes (TIL) that recognize cancer neoantigens has led to lasting remissions in metastatic melanoma and certain cases of metastatic epithelial cancer. For the treatment...
2.
Xu X, Penjweini R, Szekvolgyi L, Karanyi Z, Heckel A, Gurusamy D, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2411298122.
PMID: 39752519
Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial...
3.
White B, Sindiri S, Hill V, Gasmi B, Nah S, Gartner J, et al.
J Immunother Cancer
. 2023 Apr;
11(4).
PMID: 37045473
Background: Metastatic cholangiocarcinoma (CC), a form of gastrointestinal cancer that originates from the bile ducts, cannot be cured by currently available therapies, and is associated with dismal prognosis. In a...
4.
Palmer D, Webber B, Patel Y, Johnson M, Kariya C, Lahr W, et al.
Med
. 2022 Aug;
3(10):682-704.e8.
PMID: 36007524
Background: Adoptive transfer of tumor-infiltrating lymphocytes (TIL) fails to consistently elicit tumor rejection. Manipulation of intrinsic factors that inhibit T cell effector function and neoantigen recognition may therefore improve TIL...
5.
Kishton R, Patel S, Decker A, Vodnala S, Cam M, Yamamoto T, et al.
Cell Rep
. 2022 Aug;
40(5):111153.
PMID: 35926468
Adoptive T cell therapies (ACT) have been curative for a limited number of cancer patients. The sensitization of cancer cells to T cell killing may expand the benefit of these...
6.
Leko V, Cafri G, Yossef R, Paria B, Hill V, Gurusamy D, et al.
J Immunother Cancer
. 2021 Jul;
9(7).
PMID: 34266885
The adoptive transfer of naturally occurring T cells that recognize cancer neoantigens has led to durable tumor regressions in select patients with cancer. However, it remains unknown whether such T...
7.
Gillen J, Ondee T, Gurusamy D, Issara-Amphorn J, Manes N, Hwan Yoon S, et al.
Biomolecules
. 2021 Jan;
11(2).
PMID: 33513762
Inflammatory response plays an essential role in the resolution of infections. However, inflammation can be detrimental to an organism and cause irreparable damage. For example, during sepsis, a cytokine storm...
8.
Krishna S, Lowery F, Copeland A, Bahadiroglu E, Mukherjee R, Jia L, et al.
Science
. 2020 Dec;
370(6522):1328-1334.
PMID: 33303615
Adoptive T cell therapy (ACT) using ex vivo-expanded autologous tumor-infiltrating lymphocytes (TILs) can mediate complete regression of certain human cancers. The impact of TIL phenotypes on clinical success of TIL-ACT...
9.
Gurusamy D, Henning A, Yamamoto T, Yu Z, Zacharakis N, Krishna S, et al.
Cancer Cell
. 2020 Jun;
37(6):818-833.e9.
PMID: 32516591
T cells are central to all currently effective cancer immunotherapies, but the characteristics defining therapeutically effective anti-tumor T cells have not been comprehensively elucidated. Here, we delineate four phenotypic qualities...
10.
Xu Y, Surman D, Diggs L, Xi S, Gao S, Gurusamy D, et al.
Oncogene
. 2019 Oct;
39(4):877-890.
PMID: 31570787
Barrett's esophagus (BE) is associated with reflux and is implicated the development of esophageal adenocarcinoma (EAC). Apoptosis induces cell death through mitochondrial outer membrane permeabilization (MOMP), which is considered an...