Derek Shyr
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Explore the profile of Derek Shyr including associated specialties, affiliations and a list of published articles.
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13
Citations
157
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Recent Articles
1.
Cecchini M, Pilat M, Uboha N, Azad N, Cho M, Davis E, et al.
Cancer
. 2025 Feb;
131(4):e35755.
PMID: 39917990
Background: Neomorphic isocitrate dehydrogenase (IDH) mutations lead to the accumulation of 2-hydroxyglutarate (2-HG), an oncometabolite implicated in tumor progression via inhibitory effects on alpha-ketoglutarate. Moreover, mutant IDH-dependent accumulation of 2-HG...
2.
Shyr D, Dey R, Li X, Zhou H, Boerwinkle E, Buyske S, et al.
Am J Hum Genet
. 2024 Sep;
111(10):2129-2138.
PMID: 39270648
Large-scale, multi-ethnic whole-genome sequencing (WGS) studies, such as the National Human Genome Research Institute Genome Sequencing Program's Centers for Common Disease Genomics (CCDG), play an important role in increasing diversity...
3.
Zalay O, Bontempi D, Bitterman D, Birkbak N, Shyr D, Haugg F, et al.
medRxiv
. 2023 Sep;
PMID: 37745558
Because humans age at different rates, a person's physical appearance may yield insights into their biological age and physiological health more reliably than their chronological age. In medicine, however, appearance...
4.
Chan M, Parikh S, Shyr D, Shamasunder B, Adamkiewicz G, James-Todd T
Environ Health Perspect
. 2023 Sep;
131(9):97002.
PMID: 37702490
Background: Personal care products are a notable source of exposure to endocrine-disrupting chemicals (EDCs). Racial/ethnic differences in the use of hair products containing EDCs are reported, with women and children...
5.
McCabe S, Hammershaimb E, Cheng D, Shi A, Shyr D, Shen S, et al.
Sci Rep
. 2023 May;
13(1):8360.
PMID: 37225748
SARS-CoV-2 vaccines are useful tools to combat the Coronavirus Disease 2019 (COVID-19) pandemic, but vaccine reluctance threatens these vaccines' effectiveness. To address COVID-19 vaccine reluctance and ensure equitable distribution, understanding...
6.
Fanucci K, Pilat M, Shyr D, Shyr Y, Boerner S, Li J, et al.
Cancer Res Commun
. 2023 Mar;
3(2):192-201.
PMID: 36968138
Purpose: Isocitrate dehydrogenase () and mutations (mt) are frequent in glioma. Preclinical studies suggest mts confer "BRCAness" phenotype, a vulnerability that can be targeted through PARP inhibition. To test this...
7.
Plant-Fox A, Ma C, Al-Sayegh H, Shyr D, Lee M, Lehmann L, et al.
Pediatr Transplant
. 2022 Jan;
26(4):e14229.
PMID: 35083822
Background: Medulloblastoma outcomes have improved with craniospinal irradiation and chemotherapy, but such therapy has resulted in poor neurocognitive outcomes for young patients. Chemotherapy-only regimens with autologous transplant have been implemented...
8.
Unraveling Attributes of COVID-19 Vaccine Hesitancy and Uptake in the U.S.: A Large Nationwide Study
McCabe S, Hammershaimb E, Cheng D, Shi A, Shyr D, Shen S, et al.
medRxiv
. 2021 Apr;
PMID: 33851172
SARS-CoV-2 vaccines are powerful tools to combat the COVID-19 pandemic, but vaccine hesitancy threatens these vaccines’ effectiveness. To address COVID-19 vaccine hesitancy and ensure equitable distribution, understanding the extent of...
9.
Shyr D, Shyr Y
Expert Opin Investig Drugs
. 2020 Dec;
30(2):111-117.
PMID: 33353432
: The COVID-19 pandemic has prompted researchers to conduct non-randomized studies in an effort to find an off-label drug that can effectively combat the virus and its effects. While these...
10.
Nait Saada J, Kalantzis G, Shyr D, Cooper F, Robinson M, Gusev A, et al.
Nat Commun
. 2020 Dec;
11(1):6130.
PMID: 33257650
Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm...