Derek M Huffman
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Explore the profile of Derek M Huffman including associated specialties, affiliations and a list of published articles.
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60
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2437
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Recent Articles
1.
Mao K, Wang R, Karpoff K, Kerr D, Banerjee P, Friedman J, et al.
Geroscience
. 2025 Mar;
PMID: 40088391
Geroscience has helped to usher in a new and exciting era of aging drug development and evaluation of novel and repurposed agents, as well as natural compounds purported to target...
2.
Engel M, Narayan S, Cui M, Branch C, Zhang X, Gandy S, et al.
J Alzheimers Dis
. 2024 Nov;
103(1):113-126.
PMID: 39610283
Background: Insulin-like growth factor-1 (IGF-1) promotes neurogenesis, cell survival, and glial function, making it a promising candidate therapy in Alzheimer's disease (AD). Objective: Long arginine 3-IGF-1 (LR3-IGF-1) is a potent...
3.
Gulej R, Nyul-Toth A, Csik B, Petersen B, Faakye J, Negri S, et al.
Geroscience
. 2023 Dec;
46(1):327-347.
PMID: 38123890
Age-related impairment of neurovascular coupling (NVC; "functional hyperemia") is a critical factor in the development of vascular cognitive impairment (VCI). Recent geroscience research indicates that cell-autonomous mechanisms alone cannot explain...
4.
Adwan Shekhidem H, Sharvit L, Huffman D, Manov I, Atzmon G, Shams I
Genes (Basel)
. 2023 Apr;
14(4).
PMID: 37107603
Telomere shortening or loss of shelterin components activates DNA damage response (DDR) pathways, leading to a replicative senescence that is usually coupled with a senescence-associated secretory phenotype (SASP). Recent studies...
5.
Choi J, Houston M, Wang R, Ye K, Li W, Zhang X, et al.
Aging Cell
. 2023 Mar;
22(5):e13802.
PMID: 36864750
The intestinal epithelium consists of cells derived from continuously cycling Lgr5 intestinal stem cells (Lgr5 ISCs) that mature developmentally in an ordered fashion as the cells progress along the crypt-luminal...
6.
Novaj A, Engel M, Wang R, Mao K, Xue X, Amir Y, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768636
Evidence continues to accrue that aging and its diseases can be delayed by pharmacologic and dietary strategies that target the underlying hallmarks of the aging process. However, identifying simple, safe,...
7.
Rodriguez S, Carver C, Dosch A, Huffman D, Duke Boynton F, Ayasoufi K, et al.
Front Aging
. 2022 Oct;
3:993658.
PMID: 36276605
Surgical parabiosis enables sharing of the circulating milieu between two organisms. This powerful model presents diverse complications based on age, strain, sex, and other experimental parameters. Here, we provide an...
8.
Engel M, Smith J, Mao K, Farias Quipildor G, Cui M, Gulinello M, et al.
Geroscience
. 2022 Jul;
44(5):2491-2508.
PMID: 35798912
Insulin appears to exert salutary effects in the central nervous system (CNS). Thus, brain insulin resistance has been proposed to play a role in brain aging and dementia but is...
9.
Lei H, Huffman D, Salmon A, LeBrasseur N, Carter C, Richardson A, et al.
Aging Pathobiol Ther
. 2022 Apr;
4(1):19-22.
PMID: 35475259
Physical resilience, the capacity to respond to and recover from a stressful event, declines with advancing age. Individuals respond differently to physical stressors across their lifespans. While the biological underpinnings...
10.
Yousefzadeh M, Robbins P, Huffman D
Aging (Albany NY)
. 2022 Apr;
14(7):3325-3328.
PMID: 35417855
Parabiosis is a well-established method to facilitate a shared blood supply between two conjoined animals. In particular, the pairing of mice of dissimilar ages, termed heterochronic parabiosis, has been used...