Derek L Stemple
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Explore the profile of Derek L Stemple including associated specialties, affiliations and a list of published articles.
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72
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6027
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Recent Articles
1.
Garcia-Gonzalez J, Brock A, Parker M, Riley R, Joliffe D, Sudwarts A, et al.
Elife
. 2020 Mar;
9.
PMID: 32209227
To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F sibling groups, where each...
2.
Kim J, Lana B, Torelli S, Ryan D, Catapano F, Ala P, et al.
EMBO Rep
. 2019 Oct;
20(11):e47967.
PMID: 31566294
Dystroglycan, an extracellular matrix receptor, has essential functions in various tissues. Loss of α-dystroglycan-laminin interaction due to defective glycosylation of α-dystroglycan underlies a group of congenital muscular dystrophies often associated...
3.
Collins J, White R, Staudt N, Sealy I, Packham I, Wali N, et al.
Nat Commun
. 2019 Jun;
10(1):2792.
PMID: 31243271
The Deciphering the Mechanisms of Developmental Disorders programme has analysed the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines in order to investigate the causes of...
4.
Dooley C, Wali N, Sealy I, White R, Stemple D, Collins J, et al.
PLoS Genet
. 2019 Jun;
15(6):e1008213.
PMID: 31199790
The neural crest (NC) is a vertebrate-specific cell type that contributes to a wide range of different tissues across all three germ layers. The gene regulatory network (GRN) responsible for...
5.
Scahill C, Digby Z, Sealy I, White R, Wali N, Collins J, et al.
Wellcome Open Res
. 2018 Mar;
2:77.
PMID: 29568807
Background: Mutations in proteins involved in telomere maintenance lead to a range of human diseases, including dyskeratosis congenita, idiopathic pulmonary fibrosis and cancer. Telomerase functions to add telomeric repeats back...
6.
White R, Collins J, Sealy I, Wali N, Dooley C, Digby Z, et al.
Elife
. 2017 Nov;
6.
PMID: 29144233
We have produced an mRNA expression time course of zebrafish development across 18 time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos. Using poly(A)...
7.
Henke K, Daane J, Hawkins M, Dooley C, Busch-Nentwich E, Stemple D, et al.
Genetics
. 2017 Aug;
207(2):609-623.
PMID: 28835471
Large-scale forward genetic screens have been instrumental for identifying genes that regulate development, homeostasis, and regeneration, as well as the mechanisms of disease. The zebrafish, , is an established genetic...
8.
Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish
Scahill C, Digby Z, Sealy I, Wojciechowska S, White R, Collins J, et al.
PLoS Genet
. 2017 Aug;
13(8):e1006959.
PMID: 28806732
KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the...
9.
Nelson A, Cutty S, Gasiunas S, Deplae I, Stemple D, Wardle F
Cell Rep
. 2017 Jun;
19(13):2782-2795.
PMID: 28658625
T-box transcription factors T/Brachyury homolog A (Ta) and Tbx16 are essential for correct mesoderm development in zebrafish. The downstream transcriptional networks guiding their functional activities are poorly understood. Additionally, important...
10.
McConnell S, Hernandez K, Wcisel D, Kettleborough R, Stemple D, Yoder J, et al.
Proc Natl Acad Sci U S A
. 2016 Aug;
113(34):E5014-23.
PMID: 27493218
Antigen processing and presentation genes found within the MHC are among the most highly polymorphic genes of vertebrate genomes, providing populations with diverse immune responses to a wide array of...