Derek K OFlaherty
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Explore the profile of Derek K OFlaherty including associated specialties, affiliations and a list of published articles.
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36
Citations
361
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Recent Articles
1.
Saraya J, Sammons S, OFlaherty D
Chembiochem
. 2024 Sep;
26(1):e202400643.
PMID: 39333054
Nucleic acid conjugation methodologies involve linking the nucleic acid sequence to other (bio)molecules covalently. This typically allows for nucleic acid property enhancement whether it be for therapeutic purposes, biosensing, etc....
2.
Robinson J, Sammons S, OFlaherty D
Curr Protoc
. 2024 Aug;
4(8):e1119.
PMID: 39183585
Nonenzymatic genome replication is thought to be an important process for primitive lifeforms, but this has yet to be demonstrated experimentally. Recent studies on the nonenzymatic primer extension mechanism mediated...
3.
Ding D, Fang Z, Kim S, OFlaherty D, Jia X, Stone T, et al.
J Am Chem Soc
. 2024 Jan;
146(6):3861-3871.
PMID: 38293747
2-Thiouridine (sU) is a nucleobase modification that confers enhanced efficiency and fidelity both on modern tRNA codon translation and on nonenzymatic and ribozyme-catalyzed RNA copying. We have discovered an unusual...
4.
Saraya J, OFlaherty D
Chembiochem
. 2024 Jan;
25(6):e202300870.
PMID: 38179859
Tandem oligonucleotide synthesis (TOS) is an attractive strategy to increase automated oligonucleotide synthesis efficiency. TOS is accomplished via the introduction of an immolative linker within a single sequence composed of...
5.
Rubio-Sanchez R, OFlaherty D, Wang A, Coscia F, Petris G, Di Michele L, et al.
J Am Chem Soc
. 2021 Oct;
143(40):16589-16598.
PMID: 34597506
Self-assembling single-chain amphiphiles available in the prebiotic environment likely played a fundamental role in the advent of primitive cell cycles. However, the instability of prebiotic fatty acid-based membranes to temperature...
6.
Janicki M, Kufner C, Todd Z, Kim S, OFlaherty D, Szostak J, et al.
J Phys Chem Lett
. 2021 Jul;
12(28):6707-6713.
PMID: 34260253
Substitution of exocyclic oxygen with sulfur was shown to substantially influence the properties of RNA/DNA bases, which are crucial for prebiotic chemistry and photodynamic therapies. Upon UV irradiation, thionucleobases were...
7.
OFlaherty D, Zhou L, Szostak J
Bio Protoc
. 2021 Mar;
10(17):e3734.
PMID: 33659395
The RNA world hypothesis describes a scenario where early life forms relied on RNA to govern both inheritance and catalyze useful chemical reactions. Prior to the emergence of enzymes capable...
8.
Kim S, OFlaherty D, Giurgiu C, Zhou L, Szostak J
J Am Chem Soc
. 2021 Feb;
143(9):3267-3279.
PMID: 33636080
Recent advances in prebiotic chemistry are beginning to outline plausible pathways for the synthesis of the canonical ribonucleotides and their assembly into oligoribonucleotides. However, these reaction pathways suggest that many...
9.
Akabane-Nakata M, Erande N, Kumar P, Degaonkar R, Gilbert J, Qin J, et al.
Nucleic Acids Res
. 2021 Feb;
49(5):2435-2449.
PMID: 33577685
We recently reported the synthesis of 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides, which are based on a bicyclo[3.1.0]hexane scaffold. Here, we analyzed RNAi-mediated gene silencing activity in cell culture and demonstrated that...
10.
Zhou L, OFlaherty D, Szostak J
J Am Chem Soc
. 2020 Aug;
142(37):15961-15965.
PMID: 32820909
Our current understanding of the chemistry of the primordial genetic material is fragmentary at best. The chemical replication of oligonucleotides long enough to perform catalytic functions is particularly problematic because...