Derek A Dionne
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Explore the profile of Derek A Dionne including associated specialties, affiliations and a list of published articles.
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5
Citations
60
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0
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Recent Articles
1.
Chu C, Modi H, Ellis C, Krentz N, Skovso S, Zhao Y, et al.
Diabetes
. 2022 Sep;
71(12):2612-2631.
PMID: 36170671
Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states....
2.
Skovso S, Panzhinskiy E, Kolic J, Cen H, Dionne D, Dai X, et al.
Nat Commun
. 2022 Feb;
13(1):735.
PMID: 35136059
Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an...
3.
Dommerholt M, Dionne D, Hutchinson D, Kruit J, Johnson J
J Endocrinol
. 2018 Feb;
237(1):59-71.
PMID: 29439088
Caloric restriction (CR) is the only environmental intervention with robust evidence that it extends lifespan and delays the symptoms of aging, but its mechanisms are incompletely understood. Based on the...
4.
Page M, Skovso S, Cen H, Chiu A, Dionne D, Hutchinson D, et al.
FASEB J
. 2017 Nov;
32(3):1196-1206.
PMID: 29122848
Excess circulating insulin is associated with obesity in humans and in animal models. However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been questioned because of the absence...
5.
Dionne D, Skovso S, Templeman N, Clee S, Johnson J
Endocrinology
. 2016 May;
157(7):2724-34.
PMID: 27145011
Antiadiposity effects of caloric restriction (CR) are associated with reduced insulin/IGF-1 signaling, but it is unclear whether the effects of CR would be additive to genetically reducing circulating insulin. To...