Dennis R Clayton
Overview
Explore the profile of Dennis R Clayton including associated specialties, affiliations and a list of published articles.
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17
Citations
321
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Recent Articles
1.
Ruiz W, Clayton D, Parakala-Jain T, Dalghi M, Franks J, Apodaca G
Mol Biol Cell
. 2024 Oct;
35(11):ar139.
PMID: 39356795
The keratin cytoskeleton and associated desmosomes contribute to the mechanical stability of epithelial tissues, but their organization in native bladder umbrella cells and their responses to bladder filling are poorly...
2.
Ruiz W, Clayton D, Parakala-Jain T, Dalghi M, Franks J, Apodaca G
bioRxiv
. 2024 Jun;
PMID: 38915686
The keratin cytoskeleton and associated desmosomes contribute to the mechanical stability of epithelial tissues, but their organization in bladder umbrella cells and their responses to bladder filling are poorly understood....
3.
Dalghi M, DuRie E, Ruiz W, Clayton D, Montalbetti N, Mutchler S, et al.
Physiol Rep
. 2024 May;
12(9):e16043.
PMID: 38724885
The epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical forces including shear stress and wall tension; however, the mechanosensors that detect and respond to...
4.
Ruiz W, Clayton D, Dalghi M, Montalbetti N, Carattino M, Apodaca G
J Vis Exp
. 2022 Oct;
(188).
PMID: 36282713
In addition to forming a high-resistance barrier, the urothelium lining the renal pelvis, ureters, bladder, and proximal urethra is hypothesized to sense and transmit information about its environment to the...
5.
Clayton D, Ruiz W, Dalghi M, Montalbetti N, Carattino M, Apodaca G
Am J Physiol Renal Physiol
. 2022 Jul;
323(3):F299-F321.
PMID: 35834272
Fibroblasts are crucial to normal and abnormal organ and tissue biology, yet we lack basic insights into the fibroblasts that populate the bladder wall. Candidates may include bladder interstitial cells...
6.
Porter A, Nguyen D, Clayton D, Ruiz W, Mutchler S, Ray E, et al.
JCI Insight
. 2022 Feb;
7(5).
PMID: 35104250
Molecular chaperones are responsible for maintaining cellular homeostasis, and one such chaperone, GRP170, is an endoplasmic reticulum (ER) resident that oversees both protein biogenesis and quality control. We previously discovered...
7.
Montalbetti N, Dalghi M, Bastacky S, Clayton D, Ruiz W, Apodaca G, et al.
Am J Physiol Renal Physiol
. 2021 Nov;
322(1):F1-F13.
PMID: 34779263
Urinary tract infections (UTIs) cause bladder hyperactivity and pelvic pain, but the underlying causes of these symptoms remain unknown. We investigated whether afferent sensitization contributes to the bladder overactivity and...
8.
Dalghi M, Ruiz W, Clayton D, Montalbetti N, Daugherty S, Beckel J, et al.
JCI Insight
. 2021 Aug;
6(19).
PMID: 34464353
The mechanisms that link visceral mechanosensation to the perception of internal organ status (i.e., interoception) remain elusive. In response to bladder filling, the urothelium releases ATP, which is hypothesized to...
9.
Eaton A, Clayton D, Ruiz W, Griffiths S, Rubio M, Apodaca G
Mol Biol Cell
. 2019 Jun;
30(16):2037-2052.
PMID: 31166831
The epithelial junctional complex, composed of tight junctions, adherens junctions, desmosomes, and an associated actomyosin cytoskeleton, forms the apical junctional ring (AJR), which must maintain its continuity in the face...
10.
Dalghi M, Clayton D, Ruiz W, Al-Bataineh M, Satlin L, Kleyman T, et al.
Am J Physiol Renal Physiol
. 2019 Jun;
317(2):F303-F321.
PMID: 31166705
The proper function of the organs that make up the urinary tract (kidneys, ureters, bladder, and urethra) depends on their ability to sense and respond to mechanical forces, including shear...