Denis Klemm
Overview
Explore the profile of Denis Klemm including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
32
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Recent Articles
1.
Kopf R, Paschen C, Muller L, Kocar B, Wolfring M, Vincent M, et al.
J Pharm Biomed Anal
. 2023 Sep;
236:115651.
PMID: 37688908
Non-ionic surfactants are commonly used in parenteral protein formulations and include polysorbate 20, polysorbate 80 and poloxamer188. Recently, quantification and characterization of surfactants has generated considerable interest due to their...
2.
Chen W, Klemm D, Gregoritza K, Satya Krishna Kishore R, Stracke J, Wurth C, et al.
Eur J Pharm Biopharm
. 2023 Jul;
190:242-247.
PMID: 37524212
Free fatty acid (FFA) particles that originate from the enzymatic hydrolysis of polysorbate (PS) via co-purified host cell proteins generally appear abruptly in drug products during real-time (long-term) storage. Efforts...
3.
Paschen C, Klemm D, Graf T, Kopf R, Pinto C, Muller C, et al.
J Pharm Biomed Anal
. 2020 Oct;
192:113640.
PMID: 33002754
Polysorbates and Poloxamer 188 constitute the most common surfactants used in biopharmaceutical formulations owing to their excellent protein-stabilizing properties and good safety profiles. In recent years, however, a vast number...
4.
Gstottner C, Klemm D, Haberger M, Bathke A, Wegele H, Bell C, et al.
Anal Chem
. 2017 Dec;
90(3):2119-2125.
PMID: 29264912
Characterization of unknown monoclonal antibody (mAb) variants is important in order to identify their potential impact on safety, potency, and stability. Ion exchange chromatography (IEC) coupled with UV detection is...
5.
Keller N, Nargang T, Runck M, Kotz F, Striegel A, Sachsenheimer K, et al.
Lab Chip
. 2016 Apr;
16(9):1561-4.
PMID: 27040493
Cyclic olefin copolymer (COC) is widely used in microfluidics due to its UV-transparency, its biocompatibility and high chemical resistance. Here we present a fast and cost-effective solvent bonding technique, which...
6.
Klemm D, Hoffmann V, Wetzig K, Eckert J
Anal Bioanal Chem
. 2009 Aug;
395(6):1893-900.
PMID: 19680638
Our direct current (DC)- and radiofrequency glow discharge optical emission spectroscopy (RF-GD-OES) measurements of adsorbed organic monolayers were inspired by the work of Shimizu et al., who presented the first...