Deborah Wenkert
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Explore the profile of Deborah Wenkert including associated specialties, affiliations and a list of published articles.
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38
Citations
990
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Recent Articles
1.
Whyte M, Zhang F, Mack K, Wenkert D, Gottesman G, Ericson K, et al.
Bone
. 2024 Feb;
181:117033.
PMID: 38307176
Alkaline phosphatase (ALP) is detected in most human tissues. However, ALP activity is routinely assayed using high concentrations of artificial colorimetric substrates in phosphate-free laboratory buffers at lethal pH. Hypophosphatasia...
2.
Khursigara G, Huertas P, Wenkert D, OBrien K, Sabbagh Y
Bone
. 2023 Apr;
171:116750.
PMID: 37003563
Background: Inorganic pyrophosphate (PP) is highly regulated as it plays a critical role in the regulation of physiological mineralization. Dysregulation of plasma PP is associated with skeletal hypomineralization and pathogenic...
3.
Bray R, Hartley A, Wenkert D, Muehlemann N, Natanegara F, Harrell Jr F, et al.
Ther Innov Regul Sci
. 2022 Dec;
57(3):426-435.
PMID: 36496452
Objective And Background: We assessed current understandings in interpretation of Bayesian and traditional statistical results within the clinical researcher (non-statistician) community. Methods: Within a 22-question survey, including demographics and experience...
4.
Clark J, Muhlemann N, Natanegara F, Hartley A, Wenkert D, Wang F, et al.
Ther Innov Regul Sci
. 2022 Jan;
57(3):417-425.
PMID: 34978048
Objective And Background: The clinical trials community has been hesitant to adopt Bayesian statistical methods, which are often more flexible and efficient with more naturally interpretable results than frequentist methods....
5.
Whyte M, Zhang F, Wenkert D, Mack K, Bijanki V, Ericson K, et al.
Bone
. 2021 Sep;
154:116204.
PMID: 34547524
Hypophosphatasia (HPP) is the heritable dento-osseous disease caused by loss-of-function mutation(s) of the gene ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP is a cell-surface homodimeric phosphomonoester...
6.
Sperelakis-Beedham B, Taillandier A, Domingues C, Guberto M, Colin E, Porquet-Bordes V, et al.
Mol Genet Metab
. 2021 Feb;
132(3):198-203.
PMID: 33549410
Hypophosphatasia (HPP) is a rare inherited disease affecting bone and dental mineralization due to loss-of-function mutations in the ALPL gene encoding the tissue nonspecific alkaline phosphatase (TNSALP). Prenatal benign HPP...
7.
Cook F, Seagrove-Guffey M, Mumm S, Veis D, McAlister W, Bijanki V, et al.
Bone
. 2021 Jan;
145:115839.
PMID: 33418099
Skeletal fluorosis (SF) is endemic primarily in regions with fluoride (F)-contaminated well water, but can reflect other types of chronic F exposure. Calcium (Ca) and vitamin D (D) deficiency can...
8.
Whyte M, Aronson J, McAlister W, Weinstein R, Wenkert D, Clements K, et al.
Bone
. 2020 Dec;
145:115835.
PMID: 33360005
In 2003, we briefly reported the remarkable osteopathy of a 12-year-old boy who at age two months began fracturing his limbs with subsequent hyperplastic callus formation and expansion and fusion...
9.
Whyte M, Zhang F, Wenkert D, Mumm S, Berndt T, Kumar R
Bone
. 2020 Mar;
134:115300.
PMID: 32112990
Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces...
10.
Smith P, Gottesman G, Zhang F, Cook F, Ramirez B, Wenkert D, et al.
J Bone Miner Res
. 2020 Jan;
35(5):920-931.
PMID: 31910300
X-linked hypophosphatemia (XLH), the most prevalent heritable renal phosphate (Pi) wasting disorder, is caused by deactivating mutations of PHEX. Consequently, circulating phosphatonin FGF23 becomes elevated and hypophosphatemia in affected children...