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Debin Tian

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Articles 31
Citations 318
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Recent Articles
1.
Zhu Z, Zhou S, Tian D, Li G, Chen G, Fang D, et al.
Polymers (Basel) . 2025 Feb; 17(3). PMID: 39940513
With the rapid progression of industrialization, water pollution has emerged as an increasingly critical issue, especially due to the release of organic dyes such as methylene blue (MB), which poses...
2.
Wang B, Subramaniam S, Tian D, Mahsoub H, Heffron C, Meng X
mBio . 2024 Oct; 15(11):e0263524. PMID: 39377575
Hepatitis E virus (HEV) is distinct from other hepatotropic viruses because it is zoonotic. HEV-1 and HEV-2 exclusively infect humans, whereas HEV-3 and HEV-4 are zoonotic. However, the viral and/or...
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Mahsoub H, Heffron C, Hassebroek A, Sooryanarain H, Wang B, LeRoith T, et al.
mBio . 2023 Mar; 14(2):e0041823. PMID: 36939322
Hepatitis E virus (HEV) causes adverse clinical outcomes in pregnant women, but the underlying mechanisms remain poorly understood. To delineate the mechanisms of pregnancy-associated adverse effects during HEV infection, we...
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Wang B, Mahsoub H, Li W, Heffron C, Tian D, Hassebroek A, et al.
mBio . 2023 Feb; 14(2):e0337222. PMID: 36809085
Chronic hepatitis E virus (HEV) infection has become a significant clinical problem that requires treatment in immunocompromised individuals. In the absence of an HEV-specific antiviral, ribavirin (RBV) has been used...
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Hassebroek A, Sooryanarain H, Heffron C, Hawks S, LeRoith T, Cecere T, et al.
J Med Virol . 2023 Jan; 95(2):e28503. PMID: 36655751
The hepatitis B virus core antigen (HBcAg) tolerates insertion of foreign epitopes and maintains its ability to self-assemble into virus-like particles (VLPs). We constructed a ∆HBcAg-based VLP vaccine expressing three...
7.
Sooryanarain H, Heffron C, Mahsoub H, Hassebroek A, Wang B, Tian D, et al.
J Virol . 2022 Sep; 96(19):e0100822. PMID: 36102649
Hepatitis E virus (HEV) infection usually results in a self-limiting acute disease; however, in infected pregnant women, it is associated with increased mortality and fulminant hepatic failure. Estrogen is known...
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Wang B, Tian D, Sooryanarain H, Mahsoub H, Heffron C, Hassebroek A, et al.
Proc Natl Acad Sci U S A . 2022 Aug; 119(34):e2207503119. PMID: 35969750
Hepatitis E virus (HEV) infection in pregnant women has a high incidence of developing fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in genotype 1 HEV (HEV-1)...
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Tian D, Li W, Heffron C, Wang B, Mahsoub H, Sooryanarain H, et al.
Proc Natl Acad Sci U S A . 2022 Jun; 119(24):e2201862119. PMID: 35671427
Hepatitis E virus (HEV) is an important but understudied zoonotic virus causing both acute and chronic viral hepatitis. A proportion of HEV-infected individuals also developed neurological diseases such as Guillain-Barré...
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Nascimento Fabris Maeda D, Tian D, Yu H, Dar N, Rajasekaran V, Meng S, et al.
Proc Natl Acad Sci U S A . 2021 Apr; 118(18). PMID: 33858942
As the coronavirus disease 2019 (COVID-19) pandemic rages on, it is important to explore new evolution-resistant vaccine antigens and new vaccine platforms that can produce readily scalable, inexpensive vaccines with...