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Dayan B Goodenowe

Explore the profile of Dayan B Goodenowe including associated specialties, affiliations and a list of published articles. Areas
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Articles 30
Citations 1458
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Recent Articles
1.
Goodenowe D, Senanayake V
Front Cell Dev Biol . 2022 Sep; 10:866156. PMID: 36092723
Reduced cognition in the elderly is associated with low levels of plasmalogens and high levels of lipid rafts, amyloid plaques, and neurofibrillary tangles in the temporal cortex. A systematic integrative...
2.
Goodenowe D, Haroon J, Kling M, Zielinski M, Mahdavi K, Habelhah B, et al.
Front Cell Dev Biol . 2022 Jul; 10:864842. PMID: 35874835
Plasmalogens are a specific type of glycerophospholipid found in especially high levels in neuronal membranes. Decreased blood and brain levels of docosahexaenoic acid (DHA) containing plasmalogens are associated with decreased...
3.
Tomida S, Goodenowe D, Koyama T, Ozaki E, Kuriyama N, Morita M, et al.
Cancers (Basel) . 2021 Aug; 13(16). PMID: 34439324
The polyunsaturated fatty acid (PUFA) elongase, ELOVL5, is upregulated in breast cancer (BC) vs. adjacent normal tissue. We performed a comprehensive lipid metabolomic analysis of serum using high-resolution accurate mass...
4.
Kling M, Goodenowe D, Senanayake V, Mahmoudiandehkordi S, Arnold M, Massaro T, et al.
Alzheimers Dement . 2020 Jul; 16(9):1234-1247. PMID: 32715599
Introduction: Altered lipid metabolism is implicated in Alzheimer's disease (AD), but the mechanisms remain obscure. Aging-related declines in circulating plasmalogens containing omega-3 fatty acids may increase AD risk by reducing...
5.
Senanayake V, Goodenowe D
Alzheimers Dement (N Y) . 2019 Oct; 5:524-532. PMID: 31650009
Causation of Alzheimer's disease (AD) is not well understood. It is necessary to look beyond neuropathology to identify the underlying causes of AD and many other common neurological diseases. Lipid...
6.
Goodenowe D, Senanayake V
Brain Sci . 2019 Apr; 9(4). PMID: 31022959
Using a community sample of 1205 elderly persons, we investigated the associations and potential interactions between Apolipoprotein E ( genotype and serum phosphatidylethanolamine (PlsEtn) on cognition and dementia. For each...
7.
Ritchie S, Jayasinge D, Wang L, Goodenowe D
Anal Bioanal Chem . 2016 Aug; 408(27):7811-7823. PMID: 27562752
Many current tandem mass spectrometry (MS) methods for measuring phosphatidylcholines (PtdChos) rely only on precursor ion scanning of the common 184 m/z phosphocholine fragment with positive electrospray ionization (+ESI), and...
8.
Akita H, Ritchie S, Takemasa I, Eguchi H, Pastural E, Jin W, et al.
Pancreas . 2016 Aug; 45(10):1418-1423. PMID: 27518463
Objectives: To improve the detection of pancreatic cancer (PC), a robust diagnostic biomarker is essential. We have previously discovered 4 serum metabolites (PC-594, lysophosphatidylcholine, phosphatidylcholine, and sphingomyelin) in distinguishing patients...
9.
Senanayake V, Jin W, Mochizuki A, Chitou B, Goodenowe D
BMC Neurol . 2015 Aug; 15:154. PMID: 26311235
Background: Biochemical changes associated with multiple sclerosis (MS), and its various clinical forms have not been characterized well. Therefore, we investigated the biochemistry of MS in relation to its natural...
10.
Ritchie S, Chitou B, Zheng Q, Jayasinghe D, Jin W, Mochizuki A, et al.
World J Gastroenterol . 2015 Jun; 21(21):6604-12. PMID: 26074698
Aim: To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer (PaC) patients, and to compare its performance to CA19-9. Methods: Using tandem mass...