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Dawn E Saunders

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Articles 48
Citations 970
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Recent Articles
1.
Gill S, Rose H, Wilson M, Rodriguez Gutierrez D, Worthington L, Davies N, et al.
NMR Biomed . 2024 Feb; 37(5):e5101. PMID: 38303627
H-magnetic resonance spectroscopy (MRS) has the potential to improve the noninvasive diagnostic accuracy for paediatric brain tumours. However, studies analysing large, comprehensive, multicentre datasets are lacking, hindering translation to widespread...
2.
Murdoch R, Stotesbury H, Kawadler J, Saunders D, Kirkham F, Shmueli K
Front Neurol . 2022 Nov; 13:1000889. PMID: 36341122
Silent cerebral infarction (SCI) is the most commonly reported radiological abnormality in patients with sickle cell anemia (SCA) and is associated with future clinical stroke risk. To date, there have...
3.
Jacob M, Kawadler J, Murdoch R, Ahmed M, Tutuba H, Masamu U, et al.
Br J Haematol . 2022 Nov; 201(1):114-124. PMID: 36329651
Brain injury is a common complication of sickle cell anaemia (SCA). White matter (WM) and cortical and subcortical grey matter (GM), structures may have reduced volume in patients with SCA....
4.
Clayden J, Stotesbury H, Kawadler J, Slee A, Klbel M, Saunders D, et al.
Blood Adv . 2022 Aug; 7(11):2297-2308. PMID: 35947137
In sickle cell disease, the relative importance of reduced hemoglobin (Hb) and peripheral oxygen saturation on brain structure remains uncertain. We applied graph-theoretical analysis to diffusion magnetic resonance imaging data...
5.
Stotesbury H, Kawadler J, Clayden J, Saunders D, Hood A, Koelbel M, et al.
Front Neurol . 2022 Jul; 13:867329. PMID: 35847220
Research in sickle cell anemia (SCA) has used, with limited race-matched control data, binary categorization of patients according to the presence or absence of silent cerebral infarction (SCI). SCI have...
6.
Stotesbury H, Hales P, Hood A, Koelbel M, Kawadler J, Saunders D, et al.
Front Physiol . 2022 May; 13:865391. PMID: 35592036
Previous studies have pointed to a role for regional cerebral hemodynamic stress in neurological complications in patients with sickle cell anemia (SCA), with watershed regions identified as particularly at risk...
7.
Stotesbury H, Hales P, Koelbel M, Hood A, Kawadler J, Saunders D, et al.
J Cereb Blood Flow Metab . 2022 Jan; 42(6):1061-1077. PMID: 34986673
Prior studies have described high venous signal qualitatively using arterial spin labelling (ASL) in patients with sickle cell anemia (SCA), consistent with arteriovenous shunting. We aimed to quantify the effect...
8.
Jacob M, Stotesbury H, Kawadler J, Lapadaire W, Saunders D, Sangeda R, et al.
Stroke . 2020 Mar; 51(4):1166-1173. PMID: 32138633
Background and Purpose- Widespread reductions in white matter integrity are associated with cognitive dysfunction in sickle cell anemia. Silent cerebral infarction (SCI), vasculopathy (VSC), and low hemoglobin concentration (Hb) are...
9.
Jacob M, Saunders D, Sangeda R, Ahmed M, Tutuba H, Kussaga F, et al.
Pediatr Neurol . 2020 Mar; 107:64-70. PMID: 32111561
Background: Cerebral infarcts and vasculopathy in neurologically asymptomatic children with sickle cell anemia (SCA) have received little attention in African settings. This study aimed to establish the prevalence of silent...
10.
Stotesbury H, Kawadler J, Hales P, Saunders D, Clark C, Kirkham F
Front Neurol . 2019 Sep; 10:871. PMID: 31474929
It is well-established that patients with sickle cell disease (SCD) are at substantial risk of neurological complications, including overt and silent stroke, microstructural injury, and cognitive difficulties. Yet the underlying...