Davide Calebiro
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Explore the profile of Davide Calebiro including associated specialties, affiliations and a list of published articles.
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82
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2511
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Recent Articles
1.
Calebiro D, Miljus T, OBrien S
Trends Biochem Sci
. 2024 Nov;
50(1):46-60.
PMID: 39532582
G-protein-coupled receptors (GPCRs) are the largest family of cell receptors. They mediate the effects of a multitude of endogenous and exogenous cues, are deeply involved in human physiology and disease,...
2.
Drakopoulos A, Koszegi Z, Seier K, Hubner H, Maurel D, Sounier R, et al.
J Med Chem
. 2024 Jul;
67(15):12618-12631.
PMID: 39044606
The delta opioid receptor (δOR or DOR) is a G protein-coupled receptor (GPCR) showing a promising profile as a drug target for nociception and analgesia. Herein, we design and synthesize...
3.
Guillou A, Kemkem Y, Lafont C, Fontanaud P, Calebiro D, Campos P, et al.
Endocrinology
. 2023 Nov;
165(1).
PMID: 37934802
Detection of circulating TSH is a first-line test of thyroid dysfunction, a major health problem (affecting about 5% of the population) that, if untreated, can lead to a significant deterioration...
4.
Grimes J, Koszegi Z, Lanoiselee Y, Miljus T, OBrien S, Stepniewski T, et al.
Cell
. 2023 May;
186(10):2238-2255.e20.
PMID: 37146613
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells...
5.
Lanoiselee Y, Stanislavsky A, Calebiro D, Weron A
Phys Rev E
. 2023 Jan;
106(6-1):064127.
PMID: 36671112
In this article we study the trapped motion of a molecule undergoing diffusivity fluctuations inside a harmonic potential. For the same diffusing-diffusivity process, we investigate two possible interpretations. Depending on...
6.
Ast J, Nasteska D, Fine N, Nieves D, Koszegi Z, Lanoiselee Y, et al.
Nat Commun
. 2023 Jan;
14(1):301.
PMID: 36653347
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are widely used in the treatment of...
7.
Jobin M, Siddig S, Koszegi Z, Lanoiselee Y, Khayenko V, Sungkaworn T, et al.
Nat Commun
. 2023 Jan;
14(1):34.
PMID: 36596803
The γ-aminobutyric acid type B (GABA) receptor is a prototypical family C G protein-coupled receptor (GPCR) that plays a key role in the regulation of synaptic transmission. Although growing evidence...
8.
Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim V, et al.
Nat Commun
. 2022 Nov;
13(1):7109.
PMID: 36402762
Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of...
9.
Rahbani J, Scholtes C, Lagarde D, Hussain M, Roesler A, Dykstra C, et al.
Nat Metab
. 2022 Nov;
4(11):1459-1473.
PMID: 36344764
Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis. Aside from cAMP signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood. Here, we show that coordinated...
10.
Treppiedi D, Marra G, Di Muro G, Catalano R, Mangili F, Esposito E, et al.
Front Endocrinol (Lausanne)
. 2022 Aug;
13:892668.
PMID: 35992099
The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they...