David W Machacek
Overview
Explore the profile of David W Machacek including associated specialties, affiliations and a list of published articles.
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11
Citations
196
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Recent Articles
1.
Majumder A, Banerjee S, Harrill J, Machacek D, Mohamad O, Bacanamwo M, et al.
Stem Cells
. 2012 Aug;
30(11):2387-99.
PMID: 22899336
Various growth factor cocktails have been used to proliferate and then differentiate human neural progenitor (NP) cells derived from embryonic stem cells (ESC) for in vitro and in vivo studies....
2.
Dodla M, Young A, Venable A, Hasneen K, Rao R, Machacek D, et al.
PLoS One
. 2011 Aug;
6(8):e23266.
PMID: 21850265
Human embryonic stem cells (hESCs) and their differentiated progeny allow for investigation of important changes/events during normal embryonic development. Currently most of the research is focused on proteinacous changes occurring...
3.
Callihan P, Mumaw J, Machacek D, Stice S, Hooks S
Pharmacol Ther
. 2010 Nov;
129(3):290-306.
PMID: 21073897
Stem cell-based therapeutics have the potential to effectively treat many terminal and debilitating human diseases, but the mechanisms by which their growth and differentiation are regulated are incompletely defined. Recent...
4.
Young A, Assey K, Sturkie C, West F, Machacek D, Stice S
J Neurosci Res
. 2010 Sep;
88(15):3222-32.
PMID: 20857516
Parkinson's disease (PD) affects the motor system through the degeneration of the dopaminergic neurons of the substantia nigra. The use of human embryonic stem cell (hESC)-derived human neural progenitor (hNP)...
5.
Dhara S, Gerwe B, Majumder A, Dodla M, Boyd N, Machacek D, et al.
Tissue Eng Part A
. 2009 Oct;
15(11):3621-34.
PMID: 19795983
Human embryonic stem cell-derived neural progenitors (NP) present an important tool for understanding human development and disease. Optimal utilization of NP cells, however, requires an enhanced ability to monitor these...
6.
Hurst J, Mumaw J, Machacek D, Sturkie C, Callihan P, Stice S, et al.
BMC Neurosci
. 2008 Dec;
9:118.
PMID: 19077254
Background: Lysophospholipids regulate the morphology and growth of neurons, neural cell lines, and neural progenitors. A stable human neural progenitor cell line is not currently available in which to study...
7.
Dhara S, Hasneen K, Machacek D, Boyd N, Rao R, Stice S
Differentiation
. 2008 Jan;
76(5):454-64.
PMID: 18177420
Derivation of human neural progenitors (hNP) from human embryonic stem (hES) cells in culture has been reported with the use of feeder cells or conditioned media. This introduces undefined components...
8.
Stice S, Boyd N, Dhara S, Gerwe B, Machacek D, Shin S
Reprod Fertil Dev
. 2006 Dec;
18(8):839-46.
PMID: 17147932
Human and non-human primate embryonic stem (ES) cells are invaluable resources for developmental studies, pharmaceutical research and a better understanding of human disease and replacement therapies. In 1998, subsequent to...
9.
Machacek D, Hochman S
J Neurosci
. 2006 Jun;
26(22):5920-8.
PMID: 16738234
Spiking activity in motor axons represents the final central coding for muscle contraction. Recurrent collaterals in spinal cord from these same axons are known to offer a negative feedback control...
10.
Cui D, Dougherty K, Machacek D, Sawchuk M, Hochman S, Baro D
Physiol Genomics
. 2005 Dec;
24(3):276-89.
PMID: 16317082
Studies in the developing spinal cord suggest that different motoneuron (MN) cell types express very different genetic programs, but the degree to which adult programs differ is unknown. To compare...