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David van Zessen

Explore the profile of David van Zessen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 10
Citations 171
Followers 0
Related Specialties
Allergy & Immunology
Hematology
Pathology
Top 10 Co-Authors
Andrew P Stubbs
Mirjam van der Burg
Ingrid Pico-Knijnenburg
Hanna IJspeert
Pauline A van Schouwenburg
Jacques J M van Dongen
Prisca M J Theunissen
Peter J van der Spek
Gertjan J Driessen
Virgil A S H Dalm
Published In
Front Immunol
Diagn Pathol
Blood
Leuk Res
BMC Immunol
Affiliations
Soon will be listed here.
Recent Articles
1.
Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency
van Schouwenburg P, Unger S, Payne K, Kaiser F, Pico-Knijnenburg I, Pfeiffer J, et al.
Front Immunol . 2022 Oct; 13:959002. PMID: 36275744
Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific antibody responses, comprises a heterogeneous patient population in terms of clinical presentation and underlying...
2.
Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification
van Schouwenburg P, IJspeert H, Pico-Knijnenburg I, Dalm V, van Hagen P, van Zessen D, et al.
Front Immunol . 2018 Dec; 9:2545. PMID: 30532750
Common variable immune deficiency disorder (CVID) is the most clinically relevant cause of antibody failure. It is a highly heterogeneous disease with different underlying etiologies. CVID has been associated with...
3.
Next-generation antigen receptor sequencing of paired diagnosis and relapse samples of B-cell acute lymphoblastic leukemia: Clonal evolution and implications for minimal residual disease target selection
Theunissen P, de Bie M, van Zessen D, de Haas V, Stubbs A, van der Velden V
Leuk Res . 2018 Nov; 76:98-104. PMID: 30389174
Antigen receptor gene rearrangements are frequently applied as molecular targets for detection of minimal residual disease (MRD) in B-cell precursor acute lymphoblastic leukemia patients. Since such targets may be lost...
4.
Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones
Theunissen P, van Zessen D, Stubbs A, Faham M, Zwaan C, van Dongen J, et al.
Haematologica . 2017 Sep; 102(11):1869-1877. PMID: 28860343
In B-cell precursor acute lymphoblastic leukemia, the initial leukemic cells share the same antigen receptor gene rearrangements. However, due to ongoing rearrangement processes, leukemic cells with different gene rearrangement patterns...
5.
Antigen Receptor Galaxy: A User-Friendly, Web-Based Tool for Analysis and Visualization of T and B Cell Receptor Repertoire Data
IJspeert H, van Schouwenburg P, van Zessen D, Pico-Knijnenburg I, Stubbs A, van der Burg M
J Immunol . 2017 Apr; 198(10):4156-4165. PMID: 28416602
Antigen Receptor Galaxy (ARGalaxy) is a Web-based tool for analyses and visualization of TCR and BCR sequencing data of 13 species. ARGalaxy consists of four parts: the demultiplex tool, the...
6.
Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults
IJspeert H, van Schouwenburg P, van Zessen D, Pico-Knijnenburg I, Driessen G, Stubbs A, et al.
Front Immunol . 2016 Nov; 7:410. PMID: 27799928
Upon antigen recognition via their B cell receptor (BR), B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and...
7.
XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination
IJspeert H, Rozmus J, Schwarz K, Warren R, van Zessen D, Holt R, et al.
Blood . 2016 Jun; 128(5):650-9. PMID: 27281794
Repair of DNA double-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important not only for repair of spontaneous breaks but also for breaks induced in developing lymphocytes during...
8.
Strategies for B-cell receptor repertoire analysis in primary immunodeficiencies: from severe combined immunodeficiency to common variable immunodeficiency
IJspeert H, Wentink M, van Zessen D, Driessen G, Dalm V, van Hagen M, et al.
Front Immunol . 2015 Apr; 6:157. PMID: 25904919
The antigen receptor repertoires of B- and T-cells form the basis of the adaptive immune response. The repertoires should be sufficiently diverse to recognize all possible pathogens. However, careful selection...
9.
ImmunoGlobulin galaxy (IGGalaxy) for simple determination and quantitation of immunoglobulin heavy chain rearrangements from NGS
Moorhouse M, van Zessen D, IJspeert H, Hiltemann S, Horsman S, van der Spek P, et al.
BMC Immunol . 2014 Dec; 15:59. PMID: 25495099
Background: Sequence analysis of immunoglobulin heavy chain (IGH) gene rearrangements and frequency analysis is a powerful tool for studying the immune repertoire, immune responses and immune dysregulation in health and...
10.
Automated Selection of Hotspots (ASH): enhanced automated segmentation and adaptive step finding for Ki67 hotspot detection in adrenal cortical cancer
Lu H, Papathomas T, van Zessen D, Palli I, de Krijger R, van der Spek P, et al.
Diagn Pathol . 2014 Nov; 9:216. PMID: 25421287
Background: In prognosis and therapeutics of adrenal cortical carcinoma (ACC), the selection of the most active areas in proliferative rate (hotspots) within a slide and objective quantification of immunohistochemical Ki67...