David Schlaepfer
Overview
Explore the profile of David Schlaepfer including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
151
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0
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Recent Articles
1.
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, et al.
EMBO Mol Med
. 2020 Oct;
12(11):e12010.
PMID: 33025708
Cancer-associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target...
2.
Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, et al.
Cell Adh Migr
. 2013 Jun;
7(4):362-9.
PMID: 23751956
Procaspase-8, the zymogen form of the apoptosis-initiator caspase-8, undergoes phosphorylation following integrin-mediated cell attachment to an extracellular matrix substrate. Concordant with cell attachment to fibronectin, a population of procaspase-8 becomes...
3.
Barbero S, Mielgo A, Torres V, Teitz T, Shields D, Mikolon D, et al.
Cancer Res
. 2009 Apr;
69(9):3755-63.
PMID: 19383910
Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can...
4.
Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M, Rusnati M
J Cell Sci
. 2005 Aug;
118(Pt 17):3949-58.
PMID: 16105876
Once in the extracellular environment, the transactivator protein HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3. Real-time surface plasmon resonance analysis reveals that...