David S Libich
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Explore the profile of David S Libich including associated specialties, affiliations and a list of published articles.
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43
Citations
606
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Recent Articles
1.
Breunig K, Lei X, Montalbano M, Guardia G, Ostadrahimi S, Alers V, et al.
Elife
. 2025 Feb;
13.
PMID: 39937575
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the...
2.
Sohn E, Libich D
Mol Oncol
. 2024 Sep;
PMID: 39344201
Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex. Central to this mechanism is the...
3.
Salunkhe S, Daley J, Kaur H, Tomimatsu N, Xue C, Raina V, et al.
Nature
. 2024 Sep;
634(8033):482-491.
PMID: 39261729
The licensing step of DNA double-strand break repair by homologous recombination entails resection of DNA ends to generate a single-stranded DNA template for assembly of the repair machinery consisting of...
4.
Sohn E, Libich D
Structure
. 2024 Jul;
32(7):854-855.
PMID: 38996511
In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS and probe the molecular details of droplet aging. They observe...
5.
Breunig K, Lei X, Montalbano M, Guardia G, Ostadrahimi S, Alers V, et al.
bioRxiv
. 2024 Apr;
PMID: 38585848
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics promote liquid-liquid phase separation (LLPS) and the...
6.
Johnson C, Sojitra K, Sohn E, Moreno-Romero A, Baudin A, Xu X, et al.
J Am Chem Soc
. 2024 Mar;
146(12):8071-8085.
PMID: 38492239
The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and...
7.
Johnson C, Sojitra K, Sohn E, Moreno-Romero A, Baudin A, Xu X, et al.
bioRxiv
. 2023 Nov;
PMID: 37961424
The FET family proteins, which includes FUS, EWS, and TAF15, are RNA chaperones instrumental in processes such as mRNA maturation, transcriptional regulation, and the DNA damage response. These proteins have...
8.
Chen J, Baxi K, Lipsitt A, Hensch N, Wang L, Sreenivas P, et al.
Elife
. 2023 Jun;
12.
PMID: 37266578
In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding...
9.
Pandey S, Raut K, Clark A, Baudin A, Djemri L, Libich D, et al.
Biomolecules
. 2023 May;
13(4).
PMID: 37189414
Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40 kilodalton proapoptotic tumor suppressor,...
10.
Selig E, Bhura R, White M, Akula S, Hoffman R, Tovar C, et al.
Biopolymers
. 2023 Mar;
114(5):e23536.
PMID: 36929870
EWS is a member of the FET family of RNA/DNA binding proteins that regulate crucial phases of nucleic acid metabolism. EWS comprises an N-terminal low-complexity domain (LCD) and a C-terminal...