David S Klimstra
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Explore the profile of David S Klimstra including associated specialties, affiliations and a list of published articles.
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364
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21598
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Recent Articles
1.
Tanaka A, Ogawa M, Zhou Y, Hendrickson R, Miele M, Li Z, et al.
NPJ Precis Oncol
. 2024 Oct;
8(1):221.
PMID: 39363045
Acinar cell carcinoma (ACC) and pancreatoblastoma (PBL) are rare pancreatic malignancies with acinar differentiation. Proteogenomic profiling of ACC and PBL revealed distinct protein expression patterns compared to pancreatic ductal adenocarcinoma...
2.
Tanaka A, Ogawa M, Zhou Y, Otani Y, Hendrickson R, Miele M, et al.
iScience
. 2024 Aug;
27(8):110544.
PMID: 39206147
Pancreatic neuroendocrine tumors (PanNETs) represent well-differentiated endocrine neoplasms with variable clinical outcomes. Predicting patient outcomes using the current tumor grading system is challenging. In addition, traditional systemic treatment options for...
3.
Pareja F, Dopeso H, Wang Y, Gazzo A, Brown D, Banerjee M, et al.
Cancer Res
. 2024 Aug;
84(20):3478-3489.
PMID: 39106449
Artificial intelligence (AI) systems can improve cancer diagnosis, yet their development often relies on subjective histologic features as ground truth for training. Herein, we developed an AI model applied to...
4.
Yavas A, Ozcan K, Adsay N, Balci S, Tarcan Z, Hechtman J, et al.
Mod Pathol
. 2024 Aug;
37(11):100585.
PMID: 39094734
Inactivating alterations in the SWItch/Sucrose NonFermentable (SWI/SNF) Chromatin Remodeling Complex subunits have been described in multiple tumor types. Recent studies focused on SMARC subunits of this complex to understand their...
5.
Vorontsov E, Bozkurt A, Casson A, Shaikovski G, Zelechowski M, Severson K, et al.
Nat Med
. 2024 Jul;
30(10):2924-2935.
PMID: 39039250
The analysis of histopathology images with artificial intelligence aims to enable clinical decision support systems and precision medicine. The success of such applications depends on the ability to model the...
6.
Retamero J, Gulturk E, Bozkurt A, Liu S, Gorgan M, Moral L, et al.
Am J Surg Pathol
. 2024 May;
48(7):846-854.
PMID: 38809272
The detection of lymph node metastases is essential for breast cancer staging, although it is a tedious and time-consuming task where the sensitivity of pathologists is suboptimal. Artificial intelligence (AI)...
7.
Verschuur A, Hackeng W, Westerbeke F, Benhamida J, Basturk O, Selenica P, et al.
Clin Gastroenterol Hepatol
. 2024 Feb;
22(6):1245-1254.e10.
PMID: 38382726
Background & Aims: Cytologic and histopathologic diagnosis of non-ductal pancreatic neoplasms can be challenging in daily clinical practice, whereas it is crucial for therapy and prognosis. The cancer methylome is...
8.
Tanaka A, Ogawa M, Zhou Y, Namba K, Hendrickson R, Miele M, et al.
Cell Rep
. 2024 Feb;
43(2):113810.
PMID: 38377004
Metastatic progression of colorectal adenocarcinoma (CRC) remains poorly understood and poses significant challenges for treatment. To overcome these challenges, we performed multiomics analyses of primary CRC and liver metastases. Genomic...
9.
Yavas A, Tan J, Sahin Ozkan H, Yilmaz F, Reid M, Bagci P, et al.
Am J Surg Pathol
. 2023 Aug;
47(11):1230-1242.
PMID: 37573546
Solitary fibrous tumor (SFT) has been increasingly reported in various anatomic sites. However, it is still extremely rare in the pancreas. Herein, we present the first series of primary pancreatic...
10.
Paranal R, Jiang Z, Hutchings D, Kryklyva V, Gauthier C, Fujikura K, et al.
J Pathol
. 2023 Jun;
260(4):455-464.
PMID: 37345735
Understanding the timing and spectrum of genetic alterations that contribute to the development of pancreatic cancer is essential for effective interventions and treatments. The aim of this study was to...