David R Grosshans
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Explore the profile of David R Grosshans including associated specialties, affiliations and a list of published articles.
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121
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1919
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Recent Articles
1.
Zhang D, Thomas R, Lam T, Veselinovic I, Grosshans D
Acta Neuropathol Commun
. 2025 Mar;
13(1):59.
PMID: 40083022
Cognitive impairment is a common and challenging side effect of cranial radiation therapy for brain tumors, though its precise mechanisms remain unclear. The mesocortical dopaminergic pathway, known to play a...
2.
Bender T, Schickel E, Schielke C, Debus J, Grosshans D, Durante M, et al.
Commun Biol
. 2025 Feb;
8(1):276.
PMID: 39987290
Brain tumors are commonly treated with radiotherapy, but the efficacy of the treatment is limited by its toxicity to the normal tissue including post-irradiation contrast enhanced lesions often linked to...
3.
Schickel E, Bender T, Kaysan L, Hufgard S, Mayer M, Grosshans D, et al.
bioRxiv
. 2025 Feb;
PMID: 39974912
Efforts to achieve precise and efficient tumor targeting of highly malignant brain tumors are constrained by the dearth of appropriate models to study the effects and potential side effects of...
4.
Guan F, Bronk L, Kerr M, Li Y, Braby L, Sobieski M, et al.
Sci Rep
. 2024 Oct;
14(1):25181.
PMID: 39448656
The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry...
5.
Guan F, Jiang D, Wang X, Yang M, Iga K, Li Y, et al.
ArXiv
. 2024 Sep;
PMID: 39314510
Previously, a synchrotron-based horizontal proton beamline (87.2 MeV) was successfully commissioned to deliver radiation doses in FLASH and conventional dose rate modes to small fields and volumes. In this study,...
6.
Rubino F, Brahimaj B, Hanna E, Su S, Phan J, Grosshans D, et al.
J Neurol Surg B Skull Base
. 2024 Sep;
85(5):445-457.
PMID: 39228888
It is unclear if the length of the time interval to initiation of adjuvant radiation therapy (RT) after endoscopic endonasal surgery affects reconstruction outcomes. In this study we present our...
7.
Abu-Arja M, Brown A, Su J, Okcu M, Lindsay H, McGovern S, et al.
Neuro Oncol
. 2024 Jun;
26(10):1912-1920.
PMID: 38916058
Background: Hearing loss (HL) is associated with worse neurocognitive outcomes among patients with medulloblastoma. We aimed to identify risk factors associated with severe HL and to evaluate the generalizability of...
8.
Yang D, Zhu X, Chen M, Ma L, Cheng X, Grosshans D, et al.
Phys Med Biol
. 2024 Jun;
69(15).
PMID: 38861997
Develop a prototype on-line positron emission tomography (PET) scanner and evaluate its capability of on-line imaging and intra-fractionated proton-induced radioactivity range measurement.Each detector consists of 32 × 32 array of...
9.
Chen M, Yang D, Zhu X, Ma L, Grosshans D, Shao Y, et al.
Phys Med Biol
. 2024 Jun;
69(15).
PMID: 38861995
We previously proposed range-guided adaptive proton therapy (RGAPT) that uses mid-range treatment beams as probing beams and intra-fractionated range measurements for online adaptation. In this work, we demonstrated experimental verification...
10.
Bronk J, McAleer M, McGovern S, Lassen-Ramshad Y, Safwat A, Daw N, et al.
Radiother Oncol
. 2024 Apr;
195:110270.
PMID: 38583721
Background And Purpose: Patients with Ewing Sarcoma (EWS) are treated with multimodality therapy which includes radiation therapy (RT) as an option for local control. We report on the efficacy after...