David Quigley
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Explore the profile of David Quigley including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Seed G, Beije N, Yuan W, Bertan C, Goodall J, Lundberg A, et al.
Cancer Cell
. 2024 Nov;
42(12):2113-2123.e4.
PMID: 39577422
PARP inhibition (PARPi) has anti-tumor activity against castration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects. However, mechanisms underlying PARPi resistance are not fully understood. While acquired mutations restoring...
2.
Mandal D, Quigley D
Soft Matter
. 2024 Aug;
20(36):7174-7184.
PMID: 39206759
We study nucleation in the two dimensional Ising lattice-gas model of solute precipitation in the presence of randomly placed static and dynamic impurities. Impurity-solute and impurity-solvent interaction energies are varied...
3.
Taylor M, Kandyba E, Halliwill K, Delrosario R, Khoroshkin M, Goodarzi H, et al.
Science
. 2024 May;
384(6699):eadi7453.
PMID: 38815020
Stem cells play a critical role in cancer development by contributing to cell heterogeneity, lineage plasticity, and drug resistance. We created gene expression networks from hundreds of mouse tissue samples...
4.
Blow K, Whale T, Quigley D, Sosso G
Faraday Discuss
. 2023 Oct;
249(0):114-132.
PMID: 37782066
Understanding the mechanisms underpinning heterogeneous ice nucleation in the presence of ionic inclusions is important for fields such as cryopreservation and for improved models of climate and weather prediction. Feldspar...
5.
Blow K, Tribello G, Sosso G, Quigley D
J Chem Phys
. 2023 Jun;
158(22).
PMID: 37290068
Forward flux sampling (FFS) is a path sampling technique widely used in computer simulations of crystal nucleation from the melt. In such studies, the order parameter underpinning the progress of...
6.
Taylor M, Kandyba E, Halliwill K, Delrosario R, Koroshkin M, Goodarzi H, et al.
bioRxiv
. 2023 May;
PMID: 37215032
Adult mammalian stem cells play critical roles in normal tissue homeostasis, as well as in tumor development, by contributing to cell heterogeneity, plasticity, and development of drug resistance. The relationship...
7.
8.
Mandal D, Quigley D
J Chem Phys
. 2022 Dec;
157(21):214501.
PMID: 36511527
Nucleation is a key step in the synthesis of a new material from a solution. The well-established lattice-gas models can be used to gain insight into the basic physics of...
9.
Severson T, Qiu X, Alshalalfa M, Sjostrom M, Quigley D, Bergman A, et al.
Clin Epigenetics
. 2022 May;
14(1):60.
PMID: 35509021
The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work...
10.
Quigley D, O Donnell R, McDonnell C
BMJ Case Rep
. 2022 Mar;
15(3).
PMID: 35241446
Pulmonary lymphangitis carcinomatosis is a complication of malignancy with a poor prognosis. We describe an unusual case in which it caused ventilatory failure and unfortunately death in a previously well...