David Peretz
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Explore the profile of David Peretz including associated specialties, affiliations and a list of published articles.
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Citations
751
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Recent Articles
11.
Sigurdson C, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, et al.
J Neurosci
. 2011 Sep;
31(39):13840-7.
PMID: 21957246
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases attributed to misfolding of the cellular prion protein, PrP(C), into a β-sheet-rich, aggregated isoform, PrP(Sc). We previously found that expression of mouse PrP...
12.
Yam A, Wang X, Gao C, Connolly M, Zuckermann R, Bleu T, et al.
Biochemistry
. 2011 May;
50(20):4322-9.
PMID: 21539296
Diseases associated with the misfolding of endogenous proteins, such as Alzheimer's disease and type II diabetes, are becoming increasingly prevalent. The pathophysiology of these diseases is not totally understood, but...
13.
Gao C, Yam A, Wang X, Magdangal E, Salisbury C, Peretz D, et al.
PLoS One
. 2011 Jan;
5(12):e15725.
PMID: 21209907
Alzheimer's Disease (AD) is the most prevalent form of dementia worldwide, yet the development of therapeutics has been hampered by the absence of suitable biomarkers to diagnose the disease in...
14.
Polymenidou M, Prokop S, Jung H, Hewer E, Peretz D, Moos R, et al.
Brain Pathol
. 2010 Sep;
21(2):209-14.
PMID: 20875062
Protease-resistant prion protein (PrP(Sc) ) is diagnostic of prion disease, yet its detection is frequently difficult. Here, we describe a patient with a PRNP P105T mutation and typical familial prion...
15.
Yam A, Gao C, Wang X, Wu P, Peretz D
PLoS One
. 2010 Mar;
5(2):e9316.
PMID: 20195363
Background: Prion diseases are fatal neurodegenerative disorders characterized by misfolding and aggregation of the normal prion protein PrP(C). Little is known about the details of the structural rearrangement of physiological...
16.
Giles K, Glidden D, Beckwith R, Seoanes R, Peretz D, DeArmond S, et al.
PLoS Pathog
. 2008 Nov;
4(11):e1000206.
PMID: 19008948
Distinct prion strains often exhibit different incubation periods and patterns of neuropathological lesions. Strain characteristics are generally retained upon intraspecies transmission, but may change on transmission to another species. We...
17.
Daniak C, Peretz D, Fine J, Wang Y, Meinke A, Hale W
World J Gastroenterol
. 2008 Feb;
14(7):1084-90.
PMID: 18286691
Aim: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. Methods: A retrospective medical record review of 88 consecutive patients with...
18.
Lau A, Yam A, Michelitsch M, Wang X, Gao C, Goodson R, et al.
Proc Natl Acad Sci U S A
. 2007 Jul;
104(28):11551-6.
PMID: 17601775
On our initial discovery that prion protein (PrP)-derived peptides were capable of capturing the pathogenic prion protein (PrP(Sc)), we have been interested in how these peptides interact with PrP(Sc). After...
19.
Karpuj M, Giles K, Gelibter-Niv S, Scott M, Lingappa V, Szoka F, et al.
Mol Med
. 2007 Jun;
13(3-4):190-8.
PMID: 17592554
Prions are composed solely of the disease-causing prion protein (PrPSc) that is formed from the cellular isoform PrPC by a posttranslational process. Here we report that short phosphorothioate DNA (PS-DNA)...
20.
Legname G, Nguyen H, Peretz D, Cohen F, DeArmond S, Prusiner S
Proc Natl Acad Sci U S A
. 2006 Dec;
103(50):19105-10.
PMID: 17142317
On passaging synthetic prions, two isolates emerged with incubation times differing by nearly 100 days. Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn.HCl) concentration required to denature 50% of...