David P Toczyski
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Explore the profile of David P Toczyski including associated specialties, affiliations and a list of published articles.
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43
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1763
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Recent Articles
1.
Longhurst A, Wang K, Suresh H, Ketavarapu M, Ward H, Jones I, et al.
Elife
. 2025 Feb;
13.
PMID: 39903505
Progression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate...
2.
Longhurst A, Wang K, Suresh H, Ketavarapu M, Ward H, Jones I, et al.
bioRxiv
. 2024 Apr;
PMID: 38562687
Progression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate...
3.
Hundley F, Toczyski D
STAR Protoc
. 2021 Aug;
2(3):100685.
PMID: 34382013
The development of CRISPR-Cas9 screening techniques coupled with chemical inhibition of specific biological processes enables high-throughput investigation into many areas of molecular biology. We present a protocol to conduct ubiquitin...
4.
Hundley F, Sanvisens Delgado N, Marin H, Carr K, Tian R, Toczyski D
Mol Cell
. 2021 Feb;
81(6):1319-1336.e9.
PMID: 33539788
The human ubiquitin proteasome system, composed of over 700 ubiquitin ligases (E3s) and deubiquitinases (DUBs), has been difficult to characterize systematically and phenotypically. We performed chemical-genetic CRISPR-Cas9 screens to identify...
5.
Alme E, Toczyski D
Curr Genet
. 2020 Oct;
67(1):79-83.
PMID: 33063175
Protein phosphorylation is an essential regulatory mechanism that controls most cellular processes, integrating a variety of environmental signals to drive cellular growth. Isr1 is a negative regulator of the hexosamine...
6.
Alme E, Stevenson E, Krogan N, Swaney D, Toczyski D
PLoS Genet
. 2020 Jun;
16(6):e1008840.
PMID: 32579556
The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP),...
7.
Sanvisens Delgado N, Toczyski D
PLoS Genet
. 2019 Nov;
15(10):e1008372.
PMID: 31671089
No abstract available.
8.
Meza Gutierrez F, Simsek D, Mizrak A, Deutschbauer A, Braberg H, Johnson J, et al.
Elife
. 2018 Dec;
7.
PMID: 30547882
Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in . To uncover pathways regulated by distinct linkages, genetic...
9.
Lao J, Ulrich K, Johnson J, Newton B, Vashisht A, Wohlschlegel J, et al.
G3 (Bethesda)
. 2018 Nov;
8(12):3931-3944.
PMID: 30377154
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in...
10.
Romero A, Martinez-Pastor M, Du G, Sole C, Carlos M, Vergara S, et al.
mBio
. 2018 Sep;
9(5).
PMID: 30228242
Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional...