David P Labeda
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Explore the profile of David P Labeda including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Labeda D
Antonie Van Leeuwenhoek
. 2016 Jan;
109(3):349-56.
PMID: 26739474
Multi-locus sequence analysis has been demonstrated to be a useful tool for identification of Streptomyces species and was previously applied to phylogenetically differentiate the type strains of species pathogenic on...
12.
Ju K, Gao J, Doroghazi J, Wang K, Thibodeaux C, Li S, et al.
Proc Natl Acad Sci U S A
. 2015 Sep;
112(39):12175-80.
PMID: 26324907
Although natural products have been a particularly rich source of human medicines, activity-based screening results in a very high rate of rediscovery of known molecules. Based on the large number...
13.
Doroghazi J, Albright J, Goering A, Ju K, Haines R, Tchalukov K, et al.
Nat Chem Biol
. 2014 Sep;
10(11):963-8.
PMID: 25262415
Actinobacteria encode a wealth of natural product biosynthetic gene clusters, whose systematic study is complicated by numerous repetitive motifs. By combining several metrics, we developed a method for the global...
14.
Busarakam K, Bull A, Girard G, Labeda D, van Wezel G, Goodfellow M
Antonie Van Leeuwenhoek
. 2014 Mar;
105(5):849-61.
PMID: 24604690
A polyphasic study was carried out to establish the taxonomic status of an Atacama Desert isolate, Streptomyces strain C34(T), which synthesises novel antibiotics, the chaxalactins and chaxamycins. The organism was...
15.
Yu X, Doroghazi J, Janga S, Zhang J, Circello B, Griffin B, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
110(51):20759-64.
PMID: 24297932
Phosphonates, molecules containing direct carbon-phosphorus bonds, compose a structurally diverse class of natural products with interesting and useful biological properties. Although their synthesis in protozoa was discovered more than 50...
16.
Erol E, Sells S, Williams N, Kennedy L, Locke S, Labeda D, et al.
Vet Microbiol
. 2012 Mar;
158(3-4):425-30.
PMID: 22410309
Nocardioform placentitis associated with gram positive branching actinomycetes caused a record number of abortions in mares diagnosed by the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) affecting the 2011 foal...
17.
Kim K, Shin K, Kim M, Shin K, Labeda D, Han J, et al.
Int J Syst Evol Microbiol
. 2012 Jan;
62(Pt 12):2978-2985.
PMID: 22286909
The 16S rRNA and gyrB genes of 22 Streptomyces strains belonging to the Streptomyces griseus cluster were sequenced, and their taxonomic positions were re-evaluated. For correct analysis, all of the...
18.
Doroghazi J, Ju K, Brown D, Labeda D, Deng Z, Metcalf W, et al.
J Bacteriol
. 2011 Nov;
193(24):7021-2.
PMID: 22123769
We announce the sequencing of Streptomyces chartreusis NRRL 12338 and NRRL 3882 and Streptomyces lysosuperificus ATCC 31396. These are producers of tunicamycins, chartreusins, cephalosporins, holomycins, and calcimycin. The announced genomes,...
19.
Chen Y, Ntai I, Ju K, Unger M, Zamdborg L, Robinson S, et al.
J Proteome Res
. 2011 Oct;
11(1):85-94.
PMID: 21978092
Actinobacteria such as streptomycetes are renowned for their ability to produce bioactive natural products including nonribosomal peptides (NRPs) and polyketides (PKs). The advent of genome sequencing has revealed an even...
20.
Labeda D
Int J Syst Evol Microbiol
. 2010 Nov;
61(Pt 10):2525-2531.
PMID: 21112986
The identification and classification of species within the genus Streptomyces is difficult because there are presently 576 species with validly published names and this number increases every year. The value...