David N Wells
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Explore the profile of David N Wells including associated specialties, affiliations and a list of published articles.
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29
Citations
339
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Recent Articles
1.
Wei J, Brophy B, Cole S, Leath S, Oback B, Boch J, et al.
Reprod Fertil Dev
. 2023 Dec;
36(2):112-123.
PMID: 38064192
Context: Genome editing enables the introduction of beneficial sequence variants into the genomes of animals with high genetic merit in a single generation. This can be achieved by introducing variants...
2.
Laible G, Cole S, Brophy B, MacLean P, How Chen L, Pollock D, et al.
FASEB Bioadv
. 2020 Nov;
2(11):638-652.
PMID: 33205005
Therapeutic monoclonal antibodies (mAbs) represent one of the most important classes of pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian cells which is expensive, limiting their...
3.
van Leeuwen J, Rawson P, Berg D, Wells D, Pfeffer P
Proc Natl Acad Sci U S A
. 2020 Jul;
117(28):16409-16417.
PMID: 32601185
The polar trophoblast overlays the epiblast in eutherian mammals and, depending on the species, has one of two different fates. It either remains a single-layered, thinning epithelium called "Rauber's layer,"...
4.
Wagner S, McCracken J, Bruszies S, Broadhurst R, Wells D, Oback B, et al.
Mol Biol Rep
. 2019 Jan;
46(2):1737-1746.
PMID: 30694456
Episomal plasmids based on a scaffold/matrix attachment region (S/MAR) are extrachromosomal DNA entities that replicate once per cell cycle and are stably maintained in cells or tissue. We generated minicircles,...
5.
Wei J, Wagner S, MacLean P, Brophy B, Cole S, Smolenski G, et al.
Sci Rep
. 2018 May;
8(1):7661.
PMID: 29769555
We applied precise zygote-mediated genome editing to eliminate beta-lactoglobulin (BLG), a major allergen in cows' milk. To efficiently generate LGB knockout cows, biopsied embryos were screened to transfer only appropriately...
6.
Wagner S, Cullum A, Wells D, Laible G
Cell Reprogram
. 2017 Oct;
19(6):331-336.
PMID: 29019700
Somatic cell nuclear transfer (SCNT), commonly referred to as cloning, results in the generation of offspring that, except for mitochondrial DNA, are genetically identical to the nuclear donor. We previously...
7.
Kallingappa P, Turner P, Eichenlaub M, Green A, Oback F, Chibnall A, et al.
Biol Reprod
. 2016 Jun;
95(1):16.
PMID: 27281704
Reprogramming by nuclear transfer (NT) cloning forces cells to lose their lineage-specific epigenetic marks and reacquire totipotency. This process often produces molecular anomalies that compromise clone development. We hypothesized that...
8.
Couldrey C, MacLean P, Wells D
Cell Reprogram
. 2014 Oct;
16(6):411-7.
PMID: 25333213
Public perception of somatic cell nuclear transfer (SCNT) in the production of agricultural animals is surrounded by fear, which is exacerbated by the inability to differentiate animals generated by SCNT...
9.
van Leeuwen J, Berg D, Smith C, Wells D, Pfeffer P
PLoS One
. 2014 May;
9(5):e96843.
PMID: 24806443
Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the...
10.
Couldrey C, Wells D
PLoS One
. 2013 Feb;
8(2):e55153.
PMID: 23383311
Incomplete epigenetic reprogramming is postulated to contribute to the low developmental success following somatic cell nuclear transfer (SCNT). Here, we describe the epigenetic reprogramming of DNA methylation at an alpha...