David M Patterson
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Explore the profile of David M Patterson including associated specialties, affiliations and a list of published articles.
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15
Citations
1052
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0
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Recent Articles
1.
Yang D, Jones M, Naranjo S, Rideout 3rd W, Min K, Ho R, et al.
Cell
. 2022 May;
185(11):1905-1923.e25.
PMID: 35523183
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth and expansion to neighboring and distal tissues. The study of phylogenetic relationships between...
2.
Cabral K, Patterson D, Scheideler O, Cole R, Abate A, Schaffer D, et al.
J Vis Exp
. 2021 Mar;
(168).
PMID: 33720126
The relative positioning of cells is a key feature of the microenvironment that organizes cell-cell interactions. To study the interactions between cells of the same or different type, micropatterning techniques...
3.
Huang X, Williams J, Chang R, Li Z, Burnett C, Hernandez-Lopez R, et al.
Nat Nanotechnol
. 2020 Dec;
16(2):214-223.
PMID: 33318641
Biomaterials can improve the safety and presentation of therapeutic agents for effective immunotherapy, and a high level of control over surface functionalization is essential for immune cell modulation. Here, we...
4.
Hu K, Eichorst J, McGinnis C, Patterson D, Chow E, Kersten K, et al.
Nat Methods
. 2020 Jul;
17(8):833-843.
PMID: 32632238
Spatial transcriptomics seeks to integrate single cell transcriptomic data within the three-dimensional space of multicellular biology. Current methods to correlate a cell's position with its transcriptome in living tissues have...
5.
McGinnis C, Patterson D, Winkler J, Conrad D, Hein M, Srivastava V, et al.
Nat Methods
. 2019 Jun;
16(7):619-626.
PMID: 31209384
Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such as cell doublets. However, universal and scalable sample barcoding strategies have not been described. We therefore developed MULTI-seq: multiplexing...
6.
Liang S, van Lengerich B, Eichel K, Cha M, Patterson D, Yoon T, et al.
Cell Rep
. 2018 Mar;
22(10):2593-2600.
PMID: 29514089
Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras. Whether specific receptor conformations and oligomerization states are...
7.
Zamecnik C, Lowe M, Patterson D, Rosenblum M, Desai T
ACS Nano
. 2017 Nov;
11(11):11433-11440.
PMID: 29124929
Injectable nanomaterials that interact with the host immune system without surgical intervention present spatially anchored complements to cell transplantation and could offer improved pharmacokinetics compared to systemic cytokine therapy. Here...
8.
Patterson D, Prescher J
Curr Opin Chem Biol
. 2015 Aug;
28:141-9.
PMID: 26276062
Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable bioorthogonal chemistries, but also combinations of reactions that can...
9.
Chin P, Wright D, Zhang M, Wallace M, Roberts R, Patterson D, et al.
Drugs R D
. 2014 May;
14(2):113-23.
PMID: 24797400
Aims: Dabigatran is largely cleared by renal excretion. Renal function is thus a major determinant of trough dabigatran concentrations, which correlate with the risk of thromboembolic and haemorrhagic outcomes. Current...
10.
Patterson D, Jones K, Prescher J
Mol Biosyst
. 2014 Mar;
10(7):1693-7.
PMID: 24623192
Cyclopropenes have emerged as a new class of bioorthogonal chemical reporters. These strained rings can be metabolically introduced into target biomolecules and covalently modified via mild cycloaddition chemistries. While versatile,...