David M Gilbert
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Explore the profile of David M Gilbert including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hinojosa-Gonzalez L, Turner J, Sasaki T, Ay F, Gilbert D
bioRxiv
. 2024 Jan;
PMID: 38249518
Replication Timing (RT) refers to the temporal order in which the genome is replicated during S phase. Early replicating regions correlate with the transcriptionally active, accessible euchromatin (A) compartment, while...
12.
Nakatani T, Schauer T, Altamirano-Pacheco L, Klein K, Ettinger A, Pal M, et al.
Nature
. 2023 Dec;
625(7994):401-409.
PMID: 38123678
DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs with a defined temporal order known as the replication timing (RT) programme, leading to organization of the genome...
13.
Malzl D, Peycheva M, Rahjouei A, Gnan S, Klein K, Nazarova M, et al.
Nat Commun
. 2023 Dec;
14(1):8049.
PMID: 38081811
The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins...
14.
Kumar P, Gholamalamdari O, Zhang Y, Zhang L, Vertii A, van Schaik T, et al.
bioRxiv
. 2023 Nov;
PMID: 37961445
Genome differential positioning within interphase nuclei remains poorly explored. We extended and validated TSA-seq to map genomic regions near nucleoli and pericentric heterochromatin in four human cell lines. Our study...
15.
da Costa-Nunes J, Gierlinski M, Sasaki T, Haagensen E, Gilbert D, Blow J
Wellcome Open Res
. 2023 Sep;
8:158.
PMID: 37766844
: It has been known for many years that in metazoan cells, replication origins are organised into clusters where origins within each cluster fire near-synchronously. Despite clusters being a fundamental...
16.
Zhang M, Ehmann M, Matukumalli S, Boob A, Gilbert D, Zhao H
Nat Commun
. 2023 Sep;
14(1):5616.
PMID: 37699958
Chromatin boundary elements contribute to the partitioning of mammalian genomes into topological domains to regulate gene expression. Certain boundary elements are adopted as DNA insulators for safe and stable transgene...
17.
Corazzi L, Ionasz V, Andrejev S, Wang L, Vouzas A, Giaisi M, et al.
bioRxiv
. 2023 Sep;
PMID: 37662334
Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells. Through high-resolution replication sequencing and a capture-ligation assay in mouse neural progenitor cells experiencing...
18.
Dekker J, Alber F, Aufmkolk S, Beliveau B, Bruneau B, Belmont A, et al.
Mol Cell
. 2023 Jul;
83(15):2624-2640.
PMID: 37419111
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome and the nucleus in space and time. We summarize progress by the consortium and highlight the development of technologies...
19.
Redd P, Payero L, Gilbert D, Page C, King R, McAssey E, et al.
Front Cell Dev Biol
. 2023 Jun;
11:1184046.
PMID: 37363729
Class II DNA transposable elements account for significant portions of eukaryotic genomes and contribute to genome evolution through their mobilization. To escape inactivating mutations and persist in the host genome...
20.