David Loakes
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Explore the profile of David Loakes including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
748
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Recent Articles
1.
Pinheiro V, Loakes D, Holliger P
Bioessays
. 2013 Jan;
35(2):113-22.
PMID: 23281109
DNA and RNA are the only known natural genetic materials. Systematic modification of each of their chemical building blocks (nucleobase, sugar, and phosphate) has enabled the study of the key...
2.
Jin H, Kelley A, Loakes D, Ramakrishnan V
Proc Natl Acad Sci U S A
. 2010 Apr;
107(19):8593-8.
PMID: 20421507
We report the crystal structure of release factor 2 bound to ribosome with an aminoacyl tRNA substrate analog at the ribosomal P site, at 3.1 A resolution. The structure shows...
3.
Eustermann S, Brockmann C, Mehrotra P, Yang J, Loakes D, West S, et al.
Nat Struct Mol Biol
. 2010 Jan;
17(2):241-3.
PMID: 20098424
Addition of poly(ADP-ribose) (PAR) is an important post-translational modification in higher eukaryotes. Several DNA repair and checkpoint proteins possess specific PAR-binding zinc-finger (PBZ) modules critical for function. Here, we present...
4.
Loakes D, Gallego J, Pinheiro V, Kool E, Holliger P
J Am Chem Soc
. 2009 Sep;
131(41):14827-37.
PMID: 19778048
Hydrophobic base analogues (HBAs) have shown great promise for the expansion of the chemical and coding potential of nucleic acids but are generally poor polymerase substrates. While extensive synthetic efforts...
5.
Loakes D, Holliger P
Chem Commun (Camb)
. 2009 Jul;
(31):4619-31.
PMID: 19641798
DNA is not only a repository of genetic information for life, it is also a unique polymer with remarkable properties: it associates according to well-defined rules, it can be assembled...
6.
Loakes D, Holliger P
Mol Biosyst
. 2009 Jun;
5(7):686-94.
PMID: 19562107
The total synthesis of a simple cell is in many ways the ultimate challenge in synthetic biology. Outlined eight years ago in a visionary article by Szostak et al. (J....
7.
Voorhees R, Weixlbaumer A, Loakes D, Kelley A, Ramakrishnan V
Nat Struct Mol Biol
. 2009 Apr;
16(5):528-33.
PMID: 19363482
Protein synthesis is catalyzed in the peptidyl transferase center (PTC), located in the large (50S) subunit of the ribosome. No high-resolution structure of the intact ribosome has contained a complete...
8.
Wong T, Rajagopalan S, Townsley F, Freund S, Petrovich M, Loakes D, et al.
Nucleic Acids Res
. 2008 Dec;
37(2):568-81.
PMID: 19066201
Single-stranded DNA-binding proteins (SSB) form a class of proteins that bind preferentially single-stranded DNA with high affinity. They are involved in DNA metabolism in all organisms and serve a vital...
9.
Yung C, Loakes D, Arimoto S, Negishi K, Negishi T
Nucleic Acids Symp Ser (Oxf)
. 2008 Sep;
(52):531-2.
PMID: 18776488
Translesion synthesis (TLS), an important mechanism in cells refers to bypassing the DNA damage blockage on replication fork. Yeast TLS polymerase eta (poleta) is able to bypass 7,8-dihydro-8-oxoguanine (8-oxoG) on...
10.
Yamamoto J, Loakes D, Masutani C, Simmyo S, Urabe K, Hanaoka F, et al.
Nucleic Acids Symp Ser (Oxf)
. 2008 Sep;
(52):339-40.
PMID: 18776392
We analyzed the translesion synthesis across the UV-induced lesions, the (6-4) photoproduct and its Dewar valence isomer, by using human DNA polymerases eta and iota in vitro. The primer extension...