David L Shis
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Explore the profile of David L Shis including associated specialties, affiliations and a list of published articles.
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12
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299
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Recent Articles
1.
Picard H, Schwingen K, Green L, Shis D, Egan S, Bennett M, et al.
Proteins
. 2021 Aug;
90(1):186-199.
PMID: 34369028
To create bacterial transcription "circuits" for biotechnology, one approach is to recombine natural transcription factors, promoters, and operators. Additional novel functions can be engineered from existing transcription factors such as...
2.
Molinari S, Shis D, Bhakta S, Chappell J, Igoshin O, Bennett M
Nat Chem Biol
. 2019 Aug;
15(9):917-924.
PMID: 31406375
We describe a synthetic genetic circuit for controlling asymmetric cell division in Escherichia coli in which a progenitor cell creates a differentiated daughter cell while retaining its original phenotype. Specifically,...
3.
Zong D, Cinar S, Shis D, Josic K, Ott W, Bennett M
ACS Synth Biol
. 2018 Jul;
7(8):1834-1843.
PMID: 30040895
Recent advances in synthetic biology have led to a wealth of well-characterized genetic parts. As parts libraries grow, so too does the potential to create novel multi-input promoters that integrate...
4.
Shis D, Bennett M, Igoshin O
Annu Rev Biophys
. 2018 Mar;
47:447-467.
PMID: 29570353
The ability of bacterial cells to adjust their gene expression program in response to environmental perturbation is often critical for their survival. Recent experimental advances allowing us to quantitatively record...
5.
Chen Y, Ho J, Shis D, Gupta C, Long J, Wagner D, et al.
Nat Commun
. 2018 Jan;
9(1):64.
PMID: 29302024
One challenge for synthetic biologists is the predictable tuning of genetic circuit regulatory components to elicit desired outputs. Gene expression driven by ligand-inducible transcription factor systems must exhibit the correct...
6.
Sousa F, Parente D, Shis D, Hessman J, Chazelle A, Bennett M, et al.
J Mol Biol
. 2015 Sep;
428(4):671-678.
PMID: 26410588
Protein families evolve functional variation by accumulating point mutations at functionally important amino acid positions. Homologs in the LacI/GalR family of transcription regulators have evolved to bind diverse DNA sequences...
7.
8.
Shis D, Hussain F, Meinhardt S, Swint-Kruse L, Bennett M
ACS Synth Biol
. 2014 Jul;
3(9):645-51.
PMID: 25035932
In prokaryotes, the construction of synthetic, multi-input promoters is constrained by the number of transcription factors that can simultaneously regulate a single promoter. This fundamental engineering constraint is an obstacle...
9.
Dietrich J, Shis D, Alikhani A, Keasling J
ACS Synth Biol
. 2013 May;
2(1):47-58.
PMID: 23656325
Continued advances in metabolic engineering are increasing the number of small molecules being targeted for microbial production. Pathway yields and productivities, however, are often suboptimal, and strain improvement remains a...
10.
Schmidt C, Shis D, Nguyen-Huu T, Bennett M
ACS Synth Biol
. 2013 May;
1(10):445-50.
PMID: 23656183
Plasmid-based genetic systems in Escherichia coli are a staple of synthetic biology. However, the use of plasmids imposes limitations on the size of synthetic gene circuits and the ease with...